Paul S Cooke
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Explore the profile of Paul S Cooke including associated specialties, affiliations and a list of published articles.
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Articles
80
Citations
2036
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Recent Articles
1.
Zomer H, Cooke P
Biology (Basel)
. 2024 May;
13(5).
PMID: 38785817
Companion animal obesity has emerged as a significant veterinary health concern globally, with escalating rates posing challenges for preventive and therapeutic interventions. Obesity not only leads to immediate health problems...
2.
Simms S, Milani M, Kim M, Husain R, Infante L, Cooke P, et al.
bioRxiv
. 2024 Mar;
PMID: 38496399
Although estrogen affects the structure and function of the nervous system and brain and has a number of effects on cognition, its roles in the auditory and vestibular systems remain...
3.
Graceli J, Zomer H, Medrano T, Hess R, Korach K, Cooke P
Endocrinology
. 2023 Dec;
165(3).
PMID: 38066676
Estrogen actions are mediated by both nuclear (n) and membrane (m) localized estrogen receptor 1 (ESR1). Male Esr1 knockout (Esr1KO) mice lacking functional Esr1 are infertile, with reproductive tract abnormalities....
4.
Zomer H, Cooke P
Front Physiol
. 2023 Nov;
14:1281071.
PMID: 38028803
Non-healing skin wounds are disproportionally prevalent in older adults. Current treatments do not account for the particularities of aged skin and result in inadequate outcomes. Overall, healing chronic wounds in...
5.
Sirohi V, Medrano T, Kannan A, Bagchi I, Cooke P
iScience
. 2023 Jun;
26(7):107028.
PMID: 37360688
Maternal uterine remodeling facilitates embryo implantation, stromal cell decidualization and placentation, and perturbation of these processes may cause pregnancy loss. Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase...
6.
Walker W, Cooke P
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36769069
Steroid hormones are capable of diffusing through cell membranes to bind with intracellular receptors to regulate numerous physiological processes. Three classes of steroid hormones, namely androgens, estrogens and glucocorticoids, contribute...
7.
Mesa A, Medrano T, Sirohi V, Walker W, Johnson R, Tevosian S, et al.
Adipocyte
. 2022 Oct;
11(1):616-629.
PMID: 36260113
Brown adipose tissue (BAT) generates heat through non-shivering thermogenesis, and increasing BAT amounts or activity could facilitate obesity treatment and provide metabolic benefits. In mice, BAT has been reported in...
8.
Boregowda S, Nanjappa M, Booker C, Strivelli J, Supper V, Cooke P, et al.
Biology (Basel)
. 2022 Sep;
11(9).
PMID: 36138736
Obesity and type II diabetes mellitus (T2DM) are prominent risk factors for secondary osteoporosis due to the negative impacts of hyperglycemia and excessive body fat on bone metabolism. While the...
9.
Sirohi V, Medrano T, Mesa A, Kannan A, Bagchi I, Cooke P
Endocrinology
. 2021 Nov;
163(1).
PMID: 34791100
17β-estradiol (E2) treatment of ovariectomized adult mice stimulates the uterine PI3K-AKT signaling pathway and epithelial proliferation through estrogen receptor 1 (ESR1). However, epithelial proliferation occurs independently of E2/ESR1 signaling in...
10.
Cooke P, Walker W
Cell Rep
. 2021 Aug;
36(7):109557.
PMID: 34407397
Molecular mechanisms by which androgens signal through the androgen receptor (AR) to maintain male fertility are poorly understood. Transgenic mice were produced expressing mutant ARs that can only (1) alter...