Paul S Baxter
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Explore the profile of Paul S Baxter including associated specialties, affiliations and a list of published articles.
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13
Citations
431
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Recent Articles
1.
Baxter P, Dando O, Hardingham G
Front Mol Neurosci
. 2023 Jul;
16:1214439.
PMID: 37465362
A variety of proteins can be encoded by a single gene via the differential splicing of exons. In neurons this form of alternative splicing can be controlled by activity-dependent calcium...
2.
Anstey N, Kapgal V, Tiwari S, Watson T, Toft A, Dando O, et al.
Mol Autism
. 2022 Jul;
13(1):34.
PMID: 35850732
Background: Mutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders,...
3.
Al-Mubarak B, Bell K, Chowdhry S, Meakin P, Baxter P, McKay S, et al.
Redox Biol
. 2021 Oct;
47:102158.
PMID: 34626892
The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection of nearby neurons,...
4.
Baxter P, Dando O, Emelianova K, He X, McKay S, Hardingham G, et al.
Cell Rep
. 2021 Mar;
34(12):108882.
PMID: 33761343
Microglia, brain-resident macrophages, require instruction from the CNS microenvironment to maintain their identity and morphology and regulate inflammatory responses, although what mediates this is unclear. Here, we show that neurons...
5.
Baxter P, Markus N, Dando O, He X, Al-Mubarak B, Qiu J, et al.
Cell Death Dis
. 2021 Feb;
12(2):218.
PMID: 33637689
Many neurodegenerative diseases are associated with neuronal misfolded protein accumulation, indicating a need for proteostasis-promoting strategies. Here we show that de-repressing the transcription factor Nrf2, epigenetically shut-off in early neuronal...
6.
Booker S, Simoes de Oliveira L, Anstey N, Kozic Z, Dando O, Jackson A, et al.
Cell Rep
. 2020 Aug;
32(6):107988.
PMID: 32783927
Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here,...
7.
McKay S, Ryan T, McQueen J, Indersmitten T, Marwick K, Hasel P, et al.
Cell Rep
. 2018 Oct;
25(4):841-851.e4.
PMID: 30355491
The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes incorporated into previously GluN2B-dominated NMDARs. This "switch" is proposed to...
8.
Qiu J, Dando O, Baxter P, Hasel P, Heron S, Simpson T, et al.
Nat Protoc
. 2018 Sep;
13(10):2176-2199.
PMID: 30250293
Transcriptomic changes induced in one cell type by another mediate many biological processes in the brain and elsewhere; however, achieving artifact-free physical separation of cell types to study them is...
9.
Baxter P, Bell K, Hasel P, Kaindl A, Fricker M, Thomson D, et al.
Nat Commun
. 2017 Sep;
8:16158.
PMID: 28891555
This corrects the article DOI: 10.1038/ncomms7761.
10.
Baxter P, Hardingham G
Free Radic Biol Med
. 2016 Jul;
100:147-152.
PMID: 27365123
The human brain generally remains structurally and functionally sound for many decades, despite the post-mitotic and non-regenerative nature of neurons. This is testament to the brain's profound capacity for homeostasis:...