Paul R Murphy
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Explore the profile of Paul R Murphy including associated specialties, affiliations and a list of published articles.
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12
Citations
985
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Recent Articles
1.
Baguma-Nibasheka M, Macfarlane L, Murphy P
Genes (Basel)
. 2014 Apr;
3(3):505-20.
PMID: 24704982
Basic fibroblast growth factor (FGF2) is a potent wide-spectrum mitogen whose overexpression is associated with immortalization and unregulated cell proliferation in many tumors. The FGF2 gene locus is bi-directionally transcribed...
2.
McEachern L, Murphy P
Mol Endocrinol
. 2014 Feb;
28(4):477-89.
PMID: 24552587
Antisense transcription is prevalent in mammalian genomes, yet the function of many antisense transcripts remains elusive. We have previously shown that the fibroblast growth factor 2 (FGF2) gene is regulated...
3.
Macfarlane L, Murphy P
Curr Genomics
. 2011 May;
11(7):537-61.
PMID: 21532838
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series...
4.
Macfarlane L, Murphy P
Mol Carcinog
. 2010 Oct;
49(12):1031-44.
PMID: 20945415
Fibroblast growth factor (FGF-2) and its endogenous antisense RNA FGF antisense (FGF-AS) have been implicated in cancer progression and correlated with clinical outcomes of cancer patients. We previously reported that...
5.
Macfarlane L, Gu Y, Casson A, Murphy P
Mol Endocrinol
. 2010 Mar;
24(4):800-12.
PMID: 20197313
We have previously reported that elevated fibroblast growth factor-2 (FGF-2) expression is associated with tumor recurrence and reduced survival after surgical resection of esophageal cancer and that these risks are...
6.
Alternative splicing and differential subcellular localization of the rat FGF antisense gene product
Zhang S, MacDonald K, Baguma-Nibasheka M, Geldenhuys L, Casson A, Murphy P
BMC Mol Biol
. 2008 Jan;
9:10.
PMID: 18215310
Background: GFG/NUDT is a nudix hydrolase originally identified as the product of the fibroblast growth factor-2 antisense (FGF-AS) gene. While the FGF-AS RNA has been implicated as an antisense regulator...
7.
Thomas L, Douglas R, Lazier C, Gupta R, Norman R, Murphy P, et al.
J Urol
. 2007 Nov;
179(1):147-51.
PMID: 17997435
Purpose: In the prostate testosterone is converted to dihydrotestosterone by 5alpha-reductase type 1 and/or 2. Although 5alpha-reductase type 2 is predominant in normal prostates, type 1 is increased in cancer...
8.
Zhang S, Barclay C, Alexander L, Geldenhuys L, Porter G, Casson A, et al.
J Mol Med (Berl)
. 2007 Jun;
85(11):1215-28.
PMID: 17569023
Overexpression of FGF-2 is associated with tumor recurrence and reduced survival after surgical resection of esophageal cancer, and these risks are reduced in tumors co-expressing the FGF antisense (FGF-AS) RNA....
9.
Baguma-Nibasheka M, Barclay C, Li A, Geldenhuys L, Porter G, Blay J, et al.
Mol Carcinog
. 2007 May;
46(12):971-80.
PMID: 17477358
Inhibition of cyclooxygenase (COX)-2 is reported to suppress growth and induce apoptosis in human esophageal adenocarcinoma (EADC) cells, although the precise biologic mechanism is unclear. In this study we tested...
10.
Baguma-Nibasheka M, Li A, Murphy P
Mol Cell Endocrinol
. 2007 Feb;
267(1-2):127-36.
PMID: 17306451
Fibroblast growth factor-2 (FGF-2) is a potent heparin-binding protein with growth-promoting and anti-apoptotic activity. Transcription of the GFG/NUDT6 gene on the opposite DNA strand generates an overlapping antisense RNA (FGF-AS)...