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Paul R Gellert

Explore the profile of Paul R Gellert including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 266
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Recent Articles
1.
Anane-Adjei A, Fletcher N, Cavanagh R, Houston Z, Crawford T, Pearce A, et al.
Biomater Sci . 2022 Apr; 10(9):2328-2344. PMID: 35380131
Hyperbranched polymers have many promising features for drug delivery, owing to their ease of synthesis, multiple functional group content, and potential for high drug loading with retention of solubility. Here...
2.
Jewell A, Williams H, Hoad C, Gellert P, Ashford M, Butler J, et al.
Pharmaceutics . 2021 Sep; 13(9). PMID: 34575420
Dietary lipids and some pharmaceutical lipid excipients can facilitate the targeted delivery of drugs to the intestinal lymphatics. Here, the feasibility of magnetic resonance imaging (MRI) for imaging lipid uptake...
3.
Tchoryk A, Taresco V, Argent R, Ashford M, Gellert P, Stolnik S, et al.
Bioconjug Chem . 2019 Apr; 30(5):1371-1384. PMID: 30946570
Animal models are effective for assessing tumor localization of nanosystems but difficult to use for studying penetration beyond the vasculature. Here, we have used well-characterized HCT116 colorectal cancer spheroids to...
4.
Foralosso R, Moir L, Mastrotto F, Sasso L, Tchoryk A, Selo A, et al.
Soft Matter . 2017 Oct; 13(40):7441-7452. PMID: 28967661
A small library of thermoresponsive amphiphilic copolymers based on polylactide-block-poly((2-(2-methoxyethoxy)ethyl methacrylate)-co-(oligoethylene glycol methacrylate)) (PLA-b-P(DEGMA)-co-(OEGMA)), was synthesised by copper-mediated controlled radical polymerisation (CRP) with increasing ratios of OEGMA : DEGMA. These...
5.
Kyobula M, Adedeji A, Alexander M, Saleh E, Wildman R, Ashcroft I, et al.
J Control Release . 2017 Jul; 261:207-215. PMID: 28668378
A hot melt 3D inkjet printing method with the potential to manufacture formulations in complex and adaptable geometries for the controlled loading and release of medicines is presented. This first...
6.
Ivanov D, Parker T, Walker D, Alexander C, Ashford M, Gellert P, et al.
J Biotechnol . 2015 Jan; 205:3-13. PMID: 25592050
Physiologically relevant in vitro models can serve as biological analytical platforms for testing novel treatments and drug delivery systems. We describe the first steps in the development of a 3D...
7.
Ivanov D, Parker T, Walker D, Alexander C, Ashford M, Gellert P, et al.
PLoS One . 2014 Aug; 9(8):e103817. PMID: 25119185
Three-dimensional cell culture has many advantages over monolayer cultures, and spheroids have been hailed as the best current representation of small avascular tumours in vitro. However their adoption in regular...
8.
Scoutaris N, Hook A, Gellert P, Roberts C, Alexander M, Scurr D
J Mater Sci Mater Med . 2011 Nov; 23(2):385-91. PMID: 22083856
Three different formulations comprising two drugs, felodipine and hydrochlorothiazide (HCT) and two polymers, poly(vinyl pyrolidone) (PVP) and poly(lactic-co-glycolic acid) (PLGA) were inkjet printed as micro-dot arrays and analysed on an...
9.
Scoutaris N, Alexander M, Gellert P, Roberts C
J Control Release . 2011 Aug; 156(2):179-85. PMID: 21827800
We demonstrate the viability of using an ink-jet printer to produce a formulation capable of controlling the release of a drug. This is shown for the drug felodipine, an antihypertensive,...