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Paul R Dominguez-Gutierrez

Explore the profile of Paul R Dominguez-Gutierrez including associated specialties, affiliations and a list of published articles. Areas
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Citations 498
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Recent Articles
1.
Donelan W, Li S, Dominguez-Gutierrez P, Anderson Iv A, Yang L, Nguyen C, et al.
PLoS One . 2023 May; 18(5):e0285556. PMID: 37167324
Oxalate oxidase is an enzyme that degrades oxalate and is used in commercial urinary assays to measure oxalate levels. The objective of this study was to establish an enhanced expression...
2.
Donelan W, Dominguez-Gutierrez P, Kusmartsev S
Front Immunol . 2022 Oct; 13:971278. PMID: 36238286
Hyaluronan (HA) is known to be a prominent component of the extracellular matrix in tumors, and many solid cancers are characterized by aberrant HA metabolism resulting in increased production in...
3.
Dominguez-Gutierrez P, Kwenda E, Donelan W, Miranda M, Doty A, OMalley P, et al.
J Immunol . 2022 May; 208(12):2829-2836. PMID: 35589125
Expression of the transmembrane protein PD-L1 is frequently upregulated in cancer. Because PD-L1-expressing cells can induce apoptosis or anergy of T lymphocytes through binding to the PD1 receptor, the PD-L1-mediated...
4.
Kusmartsev S, Kwenda E, Dominguez-Gutierrez P, Crispen P, OMalley P
J Kidney Cancer VHL . 2022 May; 9(2):1-6. PMID: 35528727
Renal cell carcinoma (RCC) patients frequently have increased number of immunosuppressive myeloid cells in circulation. High number of myeloid-derived suppressor cells (MDSCs) in the blood are associated with immune suppression...
5.
Khan S, Canales B, Dominguez-Gutierrez P
Nat Rev Nephrol . 2021 Jan; 17(6):417-433. PMID: 33514941
Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque present on kidney papillary surfaces. Similar to the plaques formed during vascular calcification, Randall's plaques consist of calcium phosphate...
6.
Dominguez-Gutierrez P, Kwenda E, Donelan W, OMalley P, Crispen P, Kusmartsev S
Cancer Res . 2020 Nov; 81(3):648-657. PMID: 33239427
The increased presence of myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) in tumor tissue has been extensively reported. However, their role in the regulation of hyaluronan (HA) metabolism in...
7.
Dominguez-Gutierrez P, Kwenda E, Khan S, Canales B
Curr Opin Urol . 2020 Jan; 30(2):183-189. PMID: 31913203
Purpose Of Review: In addition to traditional risk factors such as low urine volume or hypercalciuria, emerging data suggest that calcium oxalate (CaOx), one of the most common mineral complexes...
8.
Dominguez-Gutierrez P, Kusmartsev S, Canales B, Khan S
Front Immunol . 2018 Sep; 9:1863. PMID: 30186283
Purpose: A number of hyperoxaluric states have been associated with calcium oxalate (CaOx) deposits in the kidneys. In animal models of stone disease, these crystals interact with circulating monocytes that...
9.
Kusmartsev S, Dominguez-Gutierrez P, Canales B, Bird V, Vieweg J, Khan S
J Urol . 2015 Dec; 195(4 Pt 1):1143-51. PMID: 26626217
Purpose: In murine and human hyperoxaluric conditions macrophages can be seen surrounding renal calcium oxalate crystal deposits. We hypothesized that macrophages have a role in degrading and destroying these deposits....
10.
Dominguez-Gutierrez P, Ceribelli A, Satoh M, Sobel E, Reeves W, Chan E
Arthritis Res Ther . 2014 Jan; 16(1):R23. PMID: 24460726
Introduction: Our recent data showed that signal transducers and activators of transcription 1 (STAT1), adenosine deaminase acting on RNA (ADAR), C-C motif chemokine ligand 2 (CCL2), and C-X-C motif chemokine...