Paul McKeigue
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Explore the profile of Paul McKeigue including associated specialties, affiliations and a list of published articles.
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53
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2044
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Recent Articles
1.
Goldmann K, Spiliopoulou A, Iakovliev A, Plant D, Nair N, Cubuk C, et al.
Ann Rheum Dis
. 2023 Nov;
83(3):288-299.
PMID: 37979960
Objective: Genome-wide association studies have successfully identified more than 100 loci associated with susceptibility to rheumatoid arthritis (RA). However, our understanding of the functional effects of genetic variants in causing...
2.
Lewis M, Spiliopoulou A, Goldmann K, Pitzalis C, McKeigue P, Barnes M
Bioinform Adv
. 2023 Apr;
3(1):vbad048.
PMID: 37113250
Motivation: Although machine learning models are commonly used in medical research, many analyses implement a simple partition into training data and hold-out test data, with cross-validation (CV) for tuning of...
3.
Wang H, Cordiner R, Huang Y, Donnelly L, Hapca S, Collier A, et al.
Diabetes Care
. 2023 Mar;
46(5):967-977.
PMID: 36944118
Objective: To assess the real-world cardiovascular (CV) safety for sulfonylureas (SU), in comparison with dipeptidyl peptidase 4 inhibitors (DPP4i) and thiazolidinediones (TZD), through development of robust methodology for causal inference...
4.
McKeigue P
Stat Methods Med Res
. 2022 Jun;
31(10):1934-1941.
PMID: 35642267
Joint modelling of longitudinal measurements and time to event, with longitudinal and event submodels coupled by latent state variables, has wide application in biostatistics. Standard methods for fitting these models...
5.
Shah A, Wood R, Gribben C, Caldwell D, Bishop J, Weir A, et al.
BMJ
. 2020 Oct;
371:m3582.
PMID: 33115726
Objective: To assess the risk of hospital admission for coronavirus disease 2019 (covid-19) among patient facing and non-patient facing healthcare workers and their household members. Design: Nationwide linkage cohort study....
6.
Stambuk J, Nakic N, Vuckovic F, Pucic-Bakovic M, Razdorov G, Trbojevic-Akmacic I, et al.
Aging (Albany NY)
. 2020 Aug;
12(15):15222-15259.
PMID: 32788422
Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG...
7.
Cherlin S, Lewis M, Plant D, Nair N, Goldmann K, Tzanis E, et al.
Ann Rheum Dis
. 2020 Aug;
79(11):1446-1452.
PMID: 32732242
Objectives: In this study, we sought to investigate whether there was any association between genetically regulated gene expression (as predicted using various reference panels) and anti-tumour necrosis factor (anti-TNF) treatment...
8.
Li X, Timofeeva M, Spiliopoulou A, McKeigue P, He Y, Zhang X, et al.
Int J Cancer
. 2020 Jul;
147(12):3431-3437.
PMID: 32638365
Increasing numbers of common genetic variants associated with colorectal cancer (CRC) have been identified. Our study aimed to determine whether risk prediction based on common genetic variants might enable stratification...
9.
Barbu M, Spiliopoulou A, Colombo M, McKeigue P, Clarke T, Howard D, et al.
Transl Psychiatry
. 2020 Feb;
10(1):55.
PMID: 32066731
Expression quantitative trait loci (eQTL) are genetic variants associated with gene expression. Using genome-wide genotype data, it is now possible to impute gene expression using eQTL mapping efforts. This approach...
10.
Li X, Meng X, He Y, Spiliopoulou A, Timofeeva M, Wei W, et al.
PLoS Med
. 2019 Oct;
16(10):e1002937.
PMID: 31626644
Background: The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate...