Paul M Macdonald
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Explore the profile of Paul M Macdonald including associated specialties, affiliations and a list of published articles.
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31
Citations
515
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Recent Articles
1.
Kenny A, Morgan M, Mohr S, Macdonald P
G3 (Bethesda)
. 2021 Sep;
11(12).
PMID: 34586387
The oskar transcript, acting as a noncoding RNA, contributes to a diverse set of pathways in the Drosophila ovary, including karyosome formation, positioning of the microtubule organizing center (MTOC), integrity...
2.
Kenny A, Morgan M, Macdonald P
Dev Biol
. 2021 Apr;
476:117-127.
PMID: 33798537
Drosophila oskar (osk) mRNA has both coding and noncoding functions, with the latter required for progression through oogenesis. Noncoding activity is mediated by the osk 3' UTR. Three types of...
3.
Mohr S, Kenny A, Lam S, Morgan M, Smibert C, Lipshitz H, et al.
PLoS Genet
. 2021 Apr;
17(4):e1009500.
PMID: 33798193
Localization of oskar mRNA includes two distinct phases: transport from nurse cells to the oocyte, a process typically accompanied by cortical anchoring in the oocyte, followed by posterior localization within...
4.
Ryu Y, Kenny A, Gim Y, Snee M, Macdonald P
J Cell Sci
. 2017 Aug;
130(18):3060-3071.
PMID: 28760927
Localization of mRNAs can involve multiple steps, each with its own -acting localization signals and transport factors. How is the transition between different steps orchestrated? We show that the initial...
5.
Macdonald P, Kanke M, Kenny A
Elife
. 2016 Apr;
5:e10965.
PMID: 27104756
Certain forms of translational regulation, and translation itself, rely on long-range interactions between proteins bound to the different ends of mRNAs. A widespread assumption is that such interactions occur only...
6.
Ryu Y, Macdonald P
Dev Biol
. 2015 Oct;
407(2):211-23.
PMID: 26433064
The Drosophila oskar (osk) mRNA is unusual in having both coding and noncoding functions. As an mRNA, osk encodes a protein which is deployed specifically at the posterior of the...
7.
Jones J, Macdonald P
Biol Open
. 2015 Jun;
4(8):937-46.
PMID: 26116656
Primordial germ cells (PGCs) form at the posterior pole of the Drosophila embryo, and then migrate to their final destination in the gonad where they will produce eggs or sperm....
8.
Kanke M, Macdonald P
PLoS One
. 2015 May;
10(5):e0125849.
PMID: 25938537
Local translation of oskar (osk) mRNA at the posterior pole of the Drosophila oocyte is essential for axial patterning of the embryo, and is achieved by a program of translational...
9.
Kanke M, Jambor H, Reich J, Marches B, Gstir R, Ryu Y, et al.
RNA
. 2015 Apr;
21(6):1096-109.
PMID: 25862242
The Drosophila oskar (osk) mRNA is unusual in that it has both coding and noncoding functions. As an mRNA, osk encodes a protein required for embryonic patterning and germ cell...
10.
Kim G, Pai C, Sato K, Person M, Nakamura A, Macdonald P
PLoS Genet
. 2015 Feb;
11(2):e1004992.
PMID: 25723530
A complex program of translational repression, mRNA localization, and translational activation ensures that Oskar (Osk) protein accumulates only at the posterior pole of the Drosophila oocyte. Inappropriate expression of Osk...