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Paul J Marvar

Explore the profile of Paul J Marvar including associated specialties, affiliations and a list of published articles. Areas
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Articles 47
Citations 1899
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Recent Articles
1.
Smith H, Yu Z, Iyer L, Marvar P
Biol Psychiatry Glob Open Sci . 2024 Aug; 4(5):100340. PMID: 39140003
Background: The renin-angiotensin system has been identified as a potential therapeutic target for posttraumatic stress disorder, although its mechanisms are not well understood. Brain angiotensin type 2 receptors (AT2Rs) are...
2.
Yu Z, Iyer L, Swiercz A, Paronett E, Ramadan M, Marvar P, et al.
Biol Psychiatry Glob Open Sci . 2024 Feb; 4(1):203-212. PMID: 38298799
Background: There is a growing importance for environmental contributions to psychiatric disorders and understanding the impact of the exposome (i.e., pollutants and toxins). For example, increased biomonitoring and epidemiological studies...
3.
Smith H, Yu Z, Iyer L, Marvar P
bioRxiv . 2023 Dec; PMID: 38045293
Background: The renin-angiotensin system (RAS) has been identified as a potential therapeutic target for PTSD, though its mechanisms are not well understood. Brain angiotensin type 2 receptors (AT2Rs) are a...
4.
Yu Z, Iyer L, Swiercz A, Paronett E, Ramadan M, Marvar P, et al.
bioRxiv . 2023 Oct; PMID: 37886449
There is a growing importance for environmental contributions to psychiatric disorders and understanding the impact of the exposome (i.e., pollutants and toxins). Increased biomonitoring and epidemiological studies, for example, suggest...
5.
Yu Z, Kisner A, Bhatt A, Polter A, Marvar P
Neuropharmacology . 2023 Feb; 229:109460. PMID: 36801399
The renin-angiotensin system (RAS) has been linked to the pathophysiology of posttraumatic stress disorder (PTSD) however, the underlying neurobiological mechanism(s) remain elusive. Here we utilized angiotensin II receptor type 1...
6.
Seligowski A, Webber T, Marvar P, Ressler K, Philip N
Depress Anxiety . 2022 Jun; 39(10-11):663-674. PMID: 35708302
Posttraumatic stress disorder (PTSD) has long been associated with a heightened risk of cardiovascular disease (CVD). A number of mechanisms have been implicated to underlie this brain-heart axis relationship, such...
7.
DeLaney K, Jia D, Iyer L, Yu Z, Choi S, Marvar P, et al.
Anal Chem . 2022 Jun; 94(25):9018-9025. PMID: 35696295
While the role of the renin-angiotensin system (RAS) in peripheral circulation is well characterized, we still lack an in-depth understanding of its role within the brain. This knowledge gap is...
8.
Stein M, Jain S, Simon N, West J, Marvar P, Bui E, et al.
Biol Psychiatry . 2021 Jul; 90(7):473-481. PMID: 34275593
Background: Evidence-based pharmacological treatments for posttraumatic stress disorder (PTSD) are few and of limited efficacy. Previous work suggests that angiotensin type 1 receptor inhibition facilitates fear inhibition and extinction, important...
9.
Turley B, Swiercz A, Iyer L, Marvar P
Physiol Behav . 2021 Apr; 236:113414. PMID: 33819454
To further understand mechanisms of neuropsychiatric disease(s) and their impact on physiological systems, improved pre-clinical models and innovative methodology are needed to assess the internal physiological state of the animal...
10.
Marvar P, Andero R, Hurlemann R, Lago T, Zelikowsky M, Dabrowska J
J Neurosci . 2021 Jan; 41(5):901-910. PMID: 33472824
Post-traumatic stress disorder (PTSD) is characterized by hypervigilance, increased reactivity to unpredictable versus predictable threat signals, deficits in fear extinction, and an inability to discriminate between threat and safety. First-line...