Paul J Donaldson
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Explore the profile of Paul J Donaldson including associated specialties, affiliations and a list of published articles.
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99
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1187
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Recent Articles
1.
Lim J, Jiang L, Lust N, Donaldson P
Antioxidants (Basel)
. 2024 Oct;
13(10).
PMID: 39456447
Oxidative stress plays a major role in the formation of the cataract that is the result of advancing age, diabetes or which follows vitrectomy surgery. Glutathione (GSH) is the principal...
2.
Safrina O, Vorontsova I, Donaldson P, Schilling T
Invest Ophthalmol Vis Sci
. 2024 Sep;
65(11):42.
PMID: 39330988
Purpose: Optical development of the zebrafish eye relies on the movement of the highly refractive lens nucleus from an anterior to a central location in the optical axis during development....
3.
MacFarlane E, Donaldson P, Grey A
Front Ophthalmol (Lausanne)
. 2024 Sep;
4:1414483.
PMID: 39301012
UV light is known to cause damage to biomolecules in living tissue. Tissues of the eye that play highly specialised roles in forming our sense of sight are uniquely exposed...
4.
Li B, Suzuki-Kerr H, Martis R, Lim C, Wang Z, Nguyen T, et al.
Front Ophthalmol (Lausanne)
. 2024 Aug;
4:1407582.
PMID: 39211001
Introduction: Evidence in non-ocular tissues indicate that the antioxidant glutathione (GSH) may be regulated in a circadian manner leading to the idea that GSH levels in the lens may also...
5.
Thorne C, Grey A, Lim J, Donaldson P
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201727
Cataracts are the world's leading cause of blindness, and diabetes is the second leading risk factor for cataracts after old age. Despite this, no preventative treatment exists for cataracts. The...
6.
Pan X, Muir E, Sellitto C, Jiang Z, Donaldson P, White T
Invest Ophthalmol Vis Sci
. 2024 Jul;
65(8):19.
PMID: 38984874
Purpose: The purpose of this study was to utilize multi-parametric magnetic resonance imaging (MRI) to investigate in vivo age-related changes in the physiology and optics of mouse lenses where Connexin...
7.
Li B, Jiang L, Martis R, Siemerink M, Van Severen V, Cunningham W, et al.
Exp Eye Res
. 2024 Jun;
245:109972.
PMID: 38871164
In previous work, we have shown that the lens acts a reservoir of the antioxidant glutathione (GSH), capable of exporting this antioxidant into the ocular humors and potentially protecting the...
8.
Nicolas W, Shiriaeva A, Martynowycz M, Grey A, Ruma Y, Donaldson P, et al.
bioRxiv
. 2024 May;
PMID: 38798449
Human lens fiber membrane intrinsic protein MP20 is the second most abundant membrane protein of the human eye lens. Despite decades of effort its structure and function remained elusive. Here,...
9.
Petrova R, Francis N, Schey K, Donaldson P
Exp Eye Res
. 2024 Feb;
240:109828.
PMID: 38354944
Transport of water is critical for maintaining the transparency of the avascular lens, and the lens is known to express at least five distinctly different water channels from the Aquaporin...
10.
Knight L, Martis R, Donaldson P, Acosta M, Lim J
Mol Vis
. 2024 Jan;
29:274-288.
PMID: 38222448
Purpose: The cystine/glutamate antiporter is involved in the export of intracellular glutamate in exchange for extracellular cystine. Glutamate is the main neurotransmitter in the retina and plays a key metabolic...