Paul H Taghert
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Explore the profile of Paul H Taghert including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Liang X, Holy T, Taghert P
Curr Biol
. 2023 Jan;
33(2):351-363.e3.
PMID: 36610393
Circadian clocks align various behaviors such as locomotor activity, sleep/wake, feeding, and mating to times of day that are most adaptive. How rhythmic information in pacemaker circuits is translated to...
2.
Taghert P
PLoS One
. 2022 Nov;
17(11):e0275410.
PMID: 36318573
To support studies of neuropeptide neuromodulation, I have studied beta-arrestin binding sites (BBS's) by evaluating the incidence of BBS sequences among the C terminal tails (CTs) of each of the...
3.
Li W, Trigg J, Taghert P
PLoS Genet
. 2022 May;
18(5):e1010013.
PMID: 35605015
Each day and in conjunction with ambient daylight conditions, neuropeptide PDF regulates the phase and amplitude of locomotor activity rhythms in Drosophila through its receptor, PDFR, a Family B G...
4.
Liang X, Holy T, Taghert P
Proc Natl Acad Sci U S A
. 2022 Apr;
119(17):e2109969119.
PMID: 35446620
Circadian pacemaker neurons in the Drosophila brain display daily rhythms in the levels of intracellular calcium. These calcium rhythms are driven by molecular clocks and are required for normal circadian...
5.
Yang S, McAdow J, Du Y, Trigg J, Taghert P, Johnson A
Nat Commun
. 2022 Feb;
13(1):772.
PMID: 35140224
Embryogenesis depends on a tightly regulated balance between mitosis, differentiation, and morphogenesis. Understanding how the embryo uses a relatively small number of proteins to transition between growth and morphogenesis is...
6.
Liang X, Ho M, Zhang Y, Li Y, Wu M, Holy T, et al.
Neuron
. 2019 Apr;
102(4):843-857.e4.
PMID: 30981533
Many animals exhibit morning and evening peaks of locomotor behavior. In Drosophila, two corresponding circadian neural oscillators-M (morning) cells and E (evening) cells-exhibit a corresponding morning or evening neural activity...
7.
Liang X, Holy T, Taghert P
Neuron
. 2017 May;
94(6):1173-1189.e4.
PMID: 28552314
We studied the Drosophila circadian neural circuit using whole-brain imaging in vivo. Five major groups of pacemaker neurons display synchronized molecular clocks, yet each exhibits a distinct phase of daily...
8.
Klose M, Duvall L, Li W, Liang X, Ren C, Steinbach J, et al.
Neuron
. 2016 May;
90(4):781-794.
PMID: 27161526
The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in...
9.
Liang X, Holy T, Taghert P
Science
. 2016 Feb;
351(6276):976-81.
PMID: 26917772
In Drosophila, molecular clocks control circadian rhythmic behavior through a network of ~150 pacemaker neurons. To explain how the network's neuronal properties encode time, we performed brainwide calcium imaging of...
10.
Bohn L, Lohse M, Nitabach M, Taghert P, Smit M
Mol Pharmacol
. 2015 Jul;
88(3):534-5.
PMID: 26162863
In August 2014, an international group of researchers gathered for 5 days at the Lorentz Center in Leiden, The Netherlands, to explore the technical and conceptual issues associated with the...