Paul D Acton
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Explore the profile of Paul D Acton including associated specialties, affiliations and a list of published articles.
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31
Citations
952
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Recent Articles
1.
Cai Y, Yu J, Ren P, He J, Wu Z, Xiao K, et al.
Pharmacol Res Perspect
. 2020 Jan;
8(1):e00559.
PMID: 31956418
Phosphoinositide 3-kinases, delta (PI3Kδ) and gamma (PI3Kγ) are enriched in immune cells and regulate the development and function of innate and adaptive immunity. Dual PI3Kδγ inhibitors are considered high value...
2.
Biesmans S, Bouwknecht J, Ver Donck L, Langlois X, Acton P, De Haes P, et al.
Biomed Res Int
. 2015 Aug;
2015:716920.
PMID: 26290874
Clinical observations indicate that activation of the TNF-α system may contribute to the development of inflammation-associated depression. Here, we tested the hypothesis that systemic upregulation of TNF-α induces neuroinflammation and...
3.
Biesmans S, Acton P, Cotto C, Langlois X, Ver Donck L, Bouwknecht J, et al.
Glia
. 2015 Feb;
63(7):1126-37.
PMID: 25690758
Neuroinflammation and the accompanying activation of glial cells is an important feature of many neurodegenerative conditions. It is known that factors such as peripheral infections and stress can influence immune...
4.
Biesmans S, Meert T, Bouwknecht J, Acton P, Davoodi N, De Haes P, et al.
Mediators Inflamm
. 2013 Aug;
2013:271359.
PMID: 23935246
Substantial evidence indicates an association between clinical depression and altered immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly used to study inflammation-associated behavioral changes in rodents. In these...
5.
Codd E, Ma J, Zhang S, Stone Jr D, Colburn R, Brandt M, et al.
Pharmacol Biochem Behav
. 2010 May;
96(2):130-5.
PMID: 20438745
Discovered as part of an effort to identify delta opioid (DOPr or DOR) agonist analgesics, JNJ-20788560 and JNJ-39204880 exhibited high DOR affinity, with K(i) values of 1.7 and 2.0nM, respectively,...
6.
Franc B, Acton P, Mari C, Hasegawa B
J Nucl Med
. 2008 Sep;
49(10):1651-63.
PMID: 18794275
The need to study dynamic biologic processes in intact small-animal models of disease has stimulated the development of high-resolution nuclear imaging methods. These methods are capable of clarifying molecular interactions...
7.
Thomas D, Bal H, Arkles J, Horowitz J, Araujo L, Acton P, et al.
Magn Reson Med
. 2008 Jan;
59(2):252-9.
PMID: 18228591
Acute myocardial infarction (AMI) research relies increasingly on small animal models and noninvasive imaging methods such as MRI, single-photon emission computed tomography (SPECT), and positron emission tomography (PET). However, a...
8.
Zhou R, Acton P, Ferrari V
J Am Coll Cardiol
. 2006 Nov;
48(10):2094-106.
PMID: 17112999
Stem cell-based cellular cardiomyoplasty represents a promising therapy for myocardial infarction. Noninvasive imaging techniques would allow the evaluation of survival, migration, and differentiation status of implanted stem cells in the...
9.
Shen D, Liu D, Cao Z, Acton P, Zhou R
Mol Imaging Biol
. 2006 Oct;
9(1):24-31.
PMID: 17053860
This paper demonstrates the application of mutual information based coregistration of radionuclide and magnetic resonance imaging (MRI) in an effort to use multimodality imaging for noninvasive localization of stem cells...
10.
Bal G, Acton P
Phys Med Biol
. 2006 Sep;
51(19):4923-50.
PMID: 16985279
The point spread function (PSF) of a pinhole collimator plays an important role in determining the resolution and characterizing the sensitivity of the accepted photons from a given point in...