Paul Brenchley
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Explore the profile of Paul Brenchley including associated specialties, affiliations and a list of published articles.
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1345
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Recent Articles
1.
Ragy O, Abass W, Kanigicherla D, Shinkins B, Bestall J, King N, et al.
Nephrol Dial Transplant
. 2025 Jan;
PMID: 39820570
Background And Hypothesis: The PLA2R antibody test is a valuable first-line diagnostic tool for primary membranous nephropathy (MN), helping to identify PLA2R-related MN and potentially eliminating the need for a...
2.
Hamilton P, Blaikie K, Roberts S, Gittins M, Downie M, Gupta S, et al.
PLoS One
. 2023 Apr;
18(4):e0281795.
PMID: 37104302
Background: Despite MN being one of the most common causes of nephrotic syndrome worldwide, its biological and environmental determinants are poorly understood in large-part due to it being a rare...
3.
Gupta S, Downie M, Cheshire C, Dufek-Kamperis S, Levine A, Brenchley P, et al.
Glomerular Dis
. 2023 Apr;
3(1):116-125.
PMID: 37090184
Introduction: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults and is characterized by detectable autoantibodies against glomerular antigens, most commonly phospholipase A2 receptor 1 (PLA2R1) and...
4.
Ragy O, Rautemaa V, Smith A, Brenchley P, Kanigicherla D, Hamilton P
PLoS One
. 2023 Feb;
18(2):e0281726.
PMID: 36827283
Background: Since the emergence of the anti-PLA2R antibody (PLA2R-Ab) test, nephrology practice has not changed dramatically, with most nephrologists still relying on a kidney biopsy to diagnose membranous nephropathy. In...
5.
Hamilton P, Kanigicherla D, Hanumapura P, Blaikie K, Ritchie J, Sinha S, et al.
J Clin Apher
. 2021 Nov;
37(1):40-53.
PMID: 34753218
Membranous nephropathy associated with anti-PLA R autoantibody is a significant cause of nephrotic syndrome worldwide. Treatment remains empiric with a significant side-effect burden despite an increase in our understanding of...
6.
Berchtold L, Letouze E, Alexander M, Canaud G, Logt A, Hamilton P, et al.
Kidney Int
. 2021 Jun;
100(1):243.
PMID: 34154713
No abstract available.
7.
Berchtold L, Letouze E, Alexander M, Canaud G, Logt A, Hamilton P, et al.
Kidney Int
. 2020 Sep;
99(3):671-685.
PMID: 32889013
Recurrence of primary membranous nephropathy after transplantation occurs in up to 44% of patients and is driven by PLA2R antibody. Here, we asked whether genetic determinants could improve risk prediction....
8.
Xie J, Liu L, Mladkova N, Li Y, Ren H, Wang W, et al.
Nat Commun
. 2020 Apr;
11(1):1600.
PMID: 32231244
Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 controls of East...
9.
Hamilton P, Wilson F, Chinnadurai R, Sinha S, Singh M, Ponnusamy A, et al.
Clin Kidney J
. 2020 Feb;
13(1):27-34.
PMID: 32082550
Background: Membranous nephropathy (MN) represents two distinct disease entities. Primary MN is now recognized as an autoimmune condition associated with the anti-PLAR antibody and secondary MN occurs in tandem with...
10.
Logt A, Fresquet M, Wetzels J, Brenchley P
Kidney Int
. 2019 Oct;
96(6):1292-1302.
PMID: 31611068
The discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary target in membranous nephropathy (MN) greatly advanced basic and clinical research. Primary MN is now considered...