Paul A Ginno
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Explore the profile of Paul A Ginno including associated specialties, affiliations and a list of published articles.
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6
Citations
1648
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Recent Articles
1.
Anderson C, Talmane L, Luft J, Connelly J, Nicholson M, Verburg J, et al.
Nature
. 2024 Jun;
630(8017):744-751.
PMID: 38867042
DNA base damage is a major source of oncogenic mutations. Such damage can produce strand-phased mutation patterns and multiallelic variation through the process of lesion segregation. Here we exploited these...
2.
Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, et al.
Science
. 2017 May;
356(6337).
PMID: 28473536
The majority of CpG dinucleotides in the human genome are methylated at cytosine bases. However, active gene regulatory elements are generally hypomethylated relative to their flanking regions, and the binding...
3.
Sanz L, Hartono S, Lim Y, Steyaert S, Rajpurkar A, Ginno P, et al.
Mol Cell
. 2016 Jul;
63(1):167-78.
PMID: 27373332
R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific methodology in human and...
4.
Ginno P, Lim Y, Lott P, Korf I, Chedin F
Genome Res
. 2013 Jul;
23(10):1590-600.
PMID: 23868195
Strand asymmetry in the distribution of guanines and cytosines, measured by GC skew, predisposes DNA sequences toward R-loop formation upon transcription. Previous work revealed that GC skew and R-loop formation...
5.
Ginno P, Lott P, Christensen H, Korf I, Chedin F
Mol Cell
. 2012 Mar;
45(6):814-25.
PMID: 22387027
CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of these elements remain protected from CpG methylation, a prevalent epigenetic modification associated with transcriptional silencing. Here,...
6.
Wienholz B, Kareta M, Moarefi A, Gordon C, Ginno P, Chedin F
PLoS Genet
. 2010 Sep;
6(9):e1001106.
PMID: 20838592
The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using an in vivo episomal methylation...