Patrick S Mitchell
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Explore the profile of Patrick S Mitchell including associated specialties, affiliations and a list of published articles.
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30
Citations
7358
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Recent Articles
11.
Churchill M, Mitchell P, Rauch I
J Mol Biol
. 2021 Oct;
434(4):167278.
PMID: 34627788
Pyroptosis is a lytic form of cell death that is executed by a family of pore-forming proteins called gasdermins (GSDMs). GSDMs are activated upon proteolysis by host proteases including the...
12.
Tsu B, Beierschmitt C, Ryan A, Agarwal R, Mitchell P, Daugherty M
Elife
. 2021 Jan;
10.
PMID: 33410748
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting...
13.
Mitchell P, Roncaioli J, Turcotte E, Goers L, Chavez R, Lee A, et al.
Elife
. 2020 Oct;
9.
PMID: 33074100
Bacteria of the genus cause shigellosis, a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality in humans. Mice are highly resistant to and the lack of a...
14.
Daskalov A, Mitchell P, Sandstrom A, Vance R, Glass N
Proc Natl Acad Sci U S A
. 2020 Jul;
117(31):18600-18607.
PMID: 32703806
Programmed cell death (PCD) in filamentous fungi prevents cytoplasmic mixing following fusion between conspecific genetically distinct individuals (allorecognition) and serves as a defense mechanism against mycoparasitism, genome exploitation, and deleterious...
15.
Herlin T, Jorgensen S, Host C, Mitchell P, Christensen M, Laustsen M, et al.
Rheumatology (Oxford)
. 2019 Dec;
59(9):2334-2339.
PMID: 31873740
Objectives: Here we investigated a patient with inflammatory corneal intraepithelial dyskeratosis, mucosal inflammation, tooth abnormalities and, eczema to uncover the genetic and immunological basis of the disease. Methods: On suspicion...
16.
Mitchell P, Sandstrom A, Vance R
Curr Opin Immunol
. 2019 May;
60:37-45.
PMID: 31121538
Nucleotide-binding domain, leucine-rich repeat (NLR) proteins constitute a diverse class of innate immune sensors that detect pathogens or stress-associated stimuli in plants and animals. Some NLRs are activated upon direct...
17.
Sandstrom A, Mitchell P, Goers L, Mu E, Lesser C, Vance R
Science
. 2019 Mar;
364(6435).
PMID: 30872533
Inflammasomes are multiprotein platforms that initiate innate immunity by recruitment and activation of caspase-1. The NLRP1B inflammasome is activated upon direct cleavage by the anthrax lethal toxin protease. However, the...
18.
Chavarria-Smith J, Mitchell P, Ho A, Daugherty M, Vance R
PLoS Pathog
. 2016 Dec;
12(12):e1006052.
PMID: 27926929
Inflammasomes are cytosolic multi-protein complexes that initiate immune responses to infection by recruiting and activating the Caspase-1 protease. Human NLRP1 was the first protein shown to form an inflammasome, but...
19.
Mitchell P, Young J, Emerman M, Malik H
PLoS Pathog
. 2015 Dec;
11(12):e1005304.
PMID: 26658285
Viruses impose diverse and dynamic challenges on host defenses. Diversifying selection of codons and gene copy number variation are two hallmarks of genetic innovation in antiviral genes engaged in host-virus...
20.
Huang J, Wang Y, Dhillon K, Calses P, Villegas E, Mitchell P, et al.
Mol Cancer Res
. 2013 Oct;
11(12):1564-73.
PMID: 24088786
Unlabelled: Homologous recombination mediates error-free repair of DNA double-strand breaks (DSB). RAD51 is an essential protein for catalyzing homologous recombination and its recruitment to DSBs is mediated by many factors...