Patrick Roche
Overview
Explore the profile of Patrick Roche including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
574
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0
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Recent Articles
11.
Downs-Kelly E, Yoder B, Stoler M, Tubbs R, Skacel M, Grogan T, et al.
Am J Surg Pathol
. 2005 Aug;
29(9):1221-7.
PMID: 16096413
Breast carcinomas with amplification of HER2 on chromosome 17 are associated with HER2 protein overexpression, adversely affecting prognosis and predicting response to Herceptin therapy. Chromosome 17 polysomy is encountered in...
12.
Baker D, Jeganathan K, Cameron J, Thompson M, Juneja S, Kopecka A, et al.
Nat Genet
. 2004 Jun;
36(7):744-9.
PMID: 15208629
Faithful segregation of replicated chromosomes is essential for maintenance of genetic stability and seems to be monitored by several mitotic checkpoints. Various components of these checkpoints have been identified in...
13.
Jatoi A, Suman V, Schaefer P, Block M, Loprinzi C, Roche P, et al.
Breast Cancer Res Treat
. 2003 Aug;
80(1):99-104.
PMID: 12889603
Purpose: Short chain ceramides induce tumor cell apoptosis in preclinical models. Limited therapeutic options for patients with cutaneous breast cancer prompted the testing of these sphingolipids in patients with this...
14.
Kienstra M, Neel H, Strome S, Roche P
Head Neck
. 2003 Jun;
25(6):457-63.
PMID: 12784237
Background: Certain tumor antigens have been identified that stimulate an immune response, thus making them targets for immunotherapy. NY-ESO-1, MAGE-1, and MAGE-3 are such antigens. This study was undertaken to...
15.
Tubbs R, Skacel M, Pettay J, Powell R, Myles J, Hicks D, et al.
Am J Surg Pathol
. 2002 Jul;
26(7):908-13.
PMID: 12131158
Clinical laboratory testing for HER-2/neu gene amplification by fluorescence in situ hybridization is not widely used in diagnostic pathology laboratories. A bright field alternative permitting direct visualization of gene amplification...
16.
Tubbs R, Pettay J, Skacel M, Powell R, Stoler M, Roche P, et al.
Am J Pathol
. 2002 May;
160(5):1589-95.
PMID: 12000711
Fluorescence in situ hybridization (FISH) represents an excellent method for profiling gene amplification in situ, but correlation with tissue morphology is difficult because of dark-field visualization. Validation of a bright-field...