Patrick R Secor
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Explore the profile of Patrick R Secor including associated specialties, affiliations and a list of published articles.
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45
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1728
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Recent Articles
11.
Faith D, Kinnersley M, Brooks D, Drecktrah D, Hall L, Luo E, et al.
bioRxiv
. 2024 Jan;
PMID: 38260690
Lyme disease is a tick-borne infection caused by the spirochete () . species have highly fragmented genomes composed of a linear chromosome and a constellation of linear and circular plasmids...
12.
Schwartzkopf C, Taylor V, Groleau M, Faith D, Schmidt A, Lamma T, et al.
Mol Microbiol
. 2023 Dec;
121(1):116-128.
PMID: 38038061
Quorum sensing, a bacterial signaling system that coordinates group behaviors as a function of cell density, plays an important role in regulating viral (phage) defense mechanisms in bacteria. The opportunistic...
13.
Schmidt A, Schwartzkopf C, Pourtois J, Burgener E, Faith D, Joyce A, et al.
bioRxiv
. 2023 Nov;
PMID: 38014273
is an opportunistic bacterial pathogen that commonly causes medical hardware, wound, and respiratory infections. Temperate filamentous Pf phages that infect impact numerous bacterial virulence phenotypes. Most work on Pf phages...
14.
Copeland C, Roddy J, Schmidt A, Secor P, Wheeler T
bioRxiv
. 2023 Oct;
PMID: 37905003
Bacteriophages are viruses that infect bacteria. Many bacteriophages integrate their genomes into the bacterial chromosome and become prophages. Prophages may substantially burden or benefit host bacteria fitness, acting in some...
15.
Schwartzkopf C, Taylor V, Groleau M, Faith D, Schmidt A, Lamma T, et al.
bioRxiv
. 2023 Sep;
PMID: 37662248
Quorum sensing, a bacterial signaling system that coordinates group behaviors as a function of cell density, plays an important role in regulating viral (phage) defense mechanisms in bacteria. The opportunistic...
16.
Sapiro A, Hayes B, Volk R, Zhang J, Brooks D, Martyn C, et al.
Elife
. 2023 Jul;
12.
PMID: 37449477
(), the causative agent of Lyme disease, adapts to vastly different environments as it cycles between tick vector and vertebrate host. During a tick bloodmeal, alters its gene expression to...
17.
de Mattos C, Faith D, Nemudryi A, Schmidt A, Bublitz D, Hammond L, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(9):e2216430120.
PMID: 36802441
Monitoring the extracellular environment for danger signals is a critical aspect of cellular survival. However, the danger signals released by dying bacteria and the mechanisms bacteria use for threat assessment...
18.
Schwartzkopf C, Robinson A, Ellenbecker M, Faith D, Schmidt A, Brooks D, et al.
PLoS Pathog
. 2023 Feb;
19(2):e1010925.
PMID: 36800381
The opportunistic pathogen Pseudomonas aeruginosa PAO1 is infected by the filamentous bacteriophage Pf4. Pf4 virions promote biofilm formation, protect bacteria from antibiotics, and modulate animal immune responses in ways that...
19.
Wachter J, Cheff B, Hillman C, Carracoi V, Dorward D, Martens C, et al.
Nat Commun
. 2023 Jan;
14(1):198.
PMID: 36639656
The alternative sigma factor RpoS plays a central role in the critical host-adaptive response of the Lyme disease spirochete, Borrelia burgdorferi. We previously identified bbd18 as a negative regulator of...
20.
Schmidt A, Faith D, Secor P
Cell Host Microbe
. 2023 Jan;
31(1):3-5.
PMID: 36634621
Phage-inducible chromosomal islands (PICIs) steal structural proteins from helper phages. In two related studies, Penadés and coworkers reveal that PICIs are not parasites but mutualists. Some PICIs mobilize defense systems...