Patrick M Killoran
Overview
Explore the profile of Patrick M Killoran including associated specialties, affiliations and a list of published articles.
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4
Citations
26
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Recent Articles
1.
Killoran P, Capel V, DAloisio V, Schofield A, Aczel T, Bolcskei K, et al.
J Pharm Pharmacol
. 2023 Sep;
75(12):1581-1589.
PMID: 37742055
Objectives: It has previously been shown that the peptide (34Pro,35Phe)CGRP27-37 is a potent calcitonin gene-related peptide, CGRP receptor antagonist, and in this project we aimed to improve the antagonist potency...
2.
Killoran P, Hanson G, Verhoork S, Smith M, Del Gobbo D, Lian L, et al.
Chemistry
. 2022 Dec;
29(16):e202203017.
PMID: 36550088
A method for measuring peptidylprolyl bond cis-trans conformational status in peptide models is described, using 4-fluorophenylalanine (4FPhe) as a distal reporter for F NMR. The %cis-Pro population was measured for...
3.
von Mentzer B, Russo A, Zhang Z, Kuburas A, Killoran P, DAloisio V, et al.
J Pharm Pharmacol
. 2020 Jun;
72(10):1352-1360.
PMID: 32588458
Objectives: To investigate the formulation of the peptide-based antagonist ( Pro, Phe)CGRP , of the human calcitonin gene-related peptide (CGRP) receptor as a potential nasally delivered migraine treatment. Methods: Peptide...
4.
Verhoork S, Killoran P, Coxon C
Biochemistry
. 2018 Oct;
57(43):6132-6143.
PMID: 30277385
Amide bonds at the proline nitrogen are particularly susceptible to rotation, affording cis and trans isomers. Installation of a stereochemically defined electron-withdrawing fluorine atom or fluorinated groups has the power...