Patrick J Halvey
Overview
Explore the profile of Patrick J Halvey including associated specialties, affiliations and a list of published articles.
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11
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809
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Recent Articles
1.
Halvey P, Wang X, Wang J, Bhat A, Dhawan P, Li M, et al.
Cancer Res
. 2013 Nov;
74(1):387-97.
PMID: 24247723
A growing body of genomic data on human cancers poses the critical question of how genomic variations translate to cancer phenotypes. We used standardized shotgun proteomics and targeted protein quantitation...
2.
Liu Q, Halvey P, Shyr Y, Slebos R, Liebler D, Zhang B
Mol Cell Proteomics
. 2013 Apr;
12(7):1900-11.
PMID: 23550052
MicroRNAs (miRNAs) are key post-transcriptional regulators that inhibit gene expression by promoting mRNA decay and/or suppressing translation. However, the relative contributions of these two mechanisms to gene repression remain controversial....
3.
Demory Beckler M, Higginbotham J, Franklin J, Ham A, Halvey P, Imasuen I, et al.
Mol Cell Proteomics
. 2012 Nov;
12(2):343-55.
PMID: 23161513
Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of mutant KRAS...
4.
Halvey P, Ferrone C, Liebler D
J Proteome Res
. 2012 Jun;
11(7):3908-13.
PMID: 22671702
Tumor-derived mutant KRAS (v-Ki-ras-2 Kirsten rat sarcoma viral oncogene) oncoprotein is a critical driver of cancer phenotypes and a potential biomarker for many epithelial cancers. Targeted mass spectrometry analysis by...
5.
Halvey P, Liebler D, Slebos R
FEBS Open Bio
. 2012 May;
2:56-59.
PMID: 22563532
Agents to induce readthrough of premature termination codons (PTCs) are useful research tools and potential therapeutics. Reporters used to detect PTC readthrough are gene-specific and thus are not suited to...
6.
Wang X, Slebos R, Wang D, Halvey P, Tabb D, Liebler D, et al.
J Proteome Res
. 2011 Nov;
11(2):1009-17.
PMID: 22103967
The standard shotgun proteomics data analysis strategy relies on searching MS/MS spectra against a context-independent protein sequence database derived from the complete genome sequence of an organism. Because transcriptome sequence...
7.
Halvey P, Zhang B, Coffey R, Liebler D, Slebos R
J Proteome Res
. 2011 Nov;
11(2):1184-95.
PMID: 22103262
The proteomic effects of specific cancer-related mutations have not been well characterized. In colorectal cancer (CRC), a relatively small number of mutations in key signaling pathways appear to drive tumorigenesis....
8.
Ma Z, Dasari S, Chambers M, Litton M, Sobecki S, Zimmerman L, et al.
J Proteome Res
. 2009 Jun;
8(8):3872-81.
PMID: 19522537
Tandem mass spectrometry-based shotgun proteomics has become a widespread technology for analyzing complex protein mixtures. A number of database searching algorithms have been developed to assign peptide sequences to tandem...
9.
Go Y, Halvey P, Hansen J, Reed M, Pohl J, Jones D
Am J Pathol
. 2007 Nov;
171(5):1670-81.
PMID: 17982132
Several lines of evidence suggest that an increase in aldehyde-modified proteins is associated with development of atherosclerosis. Acrolein and 4-hydroxynonenal (HNE) are reactive aldehydes generated during active inflammation as a...
10.
Halvey P, Hansen J, Johnson J, Go Y, Samali A, Jones D
Antioxid Redox Signal
. 2007 May;
9(7):807-16.
PMID: 17508907
The effects of nuclear-localized oxidative stress on both nuclear antioxidant systems, and the processes that they regulate, are not clearly understood. Here, we targeted a hydrogen peroxide (H(2)O(2))-producing enzyme, D-amino...