Alpha 2.0
Login Register
» Authors » Patrick Horne

Patrick Horne

Explore the profile of Patrick Horne including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 877
Followers 0
Related Specialties
Neurology
Molecular Biology
Science
Top 10 Co-Authors
David Westaway
Janice Robertson
Jing Yang
Teresa Sanelli
George A Carlson
Peter St George-Hyslop
Michael J Strong
Shangxi Xiao
Amie L Phinney
Catherine Bergeron
Published In
Proc Natl Acad Sci U S A
Neurol Res
Nat Med
Mol Cell Proteomics
Ann Neurol
Affiliations
Soon will be listed here.
Recent Articles
1.
Clinician barriers, perceptions, and practices in treating patients with hepatitis C virus and substance use disorder in the United States
Park H, Brown C, Wilson D, Huang P, Hernandez-Con P, Horne P, et al.
Prev Med Rep . 2023 Mar; 32:102138. PMID: 36865395
Conclusion: These findings underscore the importance of addressing patient-related barriers and prior authorization requirements-significant problematic barriers-and improving clinicians' beliefs (e.g., medication-assisted therapy should be prescribed before DAAs) and comfort levels...
2.
Evaluating the Efficacy of a Registry linked to a Consent to Re-Contact Program and Communication Strategies for Recruiting and Enrolling Participants into Clinical Trials
Flood-Grady E, Clark V, Bauer A, Morelli L, Horne P, Krieger J, et al.
Contemp Clin Trials Commun . 2018 Mar; 8:62-66. PMID: 29503877
Introduction: Although registries can rapidly identify clinical study participants, it is unknown which follow up methods for recruiting are most effective. Our goal is to examine the efficacy of three...
3.
Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis
Liu H, Sanelli T, Horne P, Pioro E, Strong M, Rogaeva E, et al.
Ann Neurol . 2009 Aug; 66(1):75-80. PMID: 19670443
Objective: In familial amyotrophic lateral sclerosis (fALS) harboring superoxide dismutase (SOD1) mutations (fALS1), SOD1 toxicity has been linked to its propensity to misfold and aggregate. It has recently been proposed...
4.
An aggregate-inducing peripherin isoform generated through intron retention is upregulated in amyotrophic lateral sclerosis and associated with disease pathology
Xiao S, Tjostheim S, Sanelli T, McLean J, Horne P, Fan Y, et al.
J Neurosci . 2008 Feb; 28(8):1833-40. PMID: 18287500
The neuronal intermediate filament protein peripherin is a component of ubiquitinated inclusions and of axonal spheroids in amyotrophic lateral sclerosis (ALS). Overexpression of peripherin causes motor neuron degeneration in transgenic...
5.
Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis
Sanelli T, Xiao S, Horne P, Bilbao J, Zinman L, Robertson J
J Neuropathol Exp Neurol . 2007 Dec; 66(12):1147-53. PMID: 18090923
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by the presence of various types of ubiquitinated inclusions in the cytoplasm of affected motor neurons. The identification of the...
6.
The in vivo brain interactome of the amyloid precursor protein
Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, et al.
Mol Cell Proteomics . 2007 Oct; 7(1):15-34. PMID: 17934213
Despite intense research efforts, the physiological function and molecular environment of the amyloid precursor protein has remained enigmatic. Here we describe the application of time-controlled transcardiac perfusion cross-linking, a method...
7.
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections
Watts J, Drisaldi B, Ng V, Yang J, Strome B, Horne P, et al.
EMBO J . 2007 Aug; 26(17):4038-50. PMID: 17703189
The cellular prion protein, PrP(C), is neuroprotective in a number of settings and in particular prevents cerebellar degeneration mediated by CNS-expressed Doppel or internally deleted PrP ('DeltaPrP'). This paradigm has...
8.
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS
Robertson J, Sanelli T, Xiao S, Yang W, Horne P, Hammond R, et al.
Neurosci Lett . 2007 Jun; 420(2):128-32. PMID: 17543992
Mislocalization of the TAR-DNA binding protein (TDP-43) from the nucleus to the cytoplasm of diseased motor neurons and association with intraneuronal ubiquitinated inclusions has recently been reported in amyotrophic lateral...
9.
An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS
Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth D, Griffin J, et al.
Nat Med . 2007 May; 13(6):754-9. PMID: 17486090
Misfolding of Cu/Zn-superoxide dismutase (SOD1) is emerging as a mechanism underlying motor neuron degeneration in individuals with amyotrophic lateral sclerosis (ALS) who carry a mutant SOD1 gene (SOD1 ALS). Here...
10.
Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation
Murakami T, Paitel E, Kawarabayashi T, Ikeda M, Chishti M, Janus C, et al.
Am J Pathol . 2006 Sep; 169(4):1365-75. PMID: 17003492
Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTauP301L) mice expressing a frontotemporal dementia with parkinsonism linked to...