Patrick Concannon
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Explore the profile of Patrick Concannon including associated specialties, affiliations and a list of published articles.
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124
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6404
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Recent Articles
1.
Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer
Reiner A, Watt G, Malone K, Lynch C, John E, Knight J, et al.
JAMA Netw Open
. 2025 Jan;
7(12):e2452158.
PMID: 39786405
Importance: Heterogeneity in development of estrogen receptor (ER)-specific first primary breast cancer exists due to deleterious germline variants in moderate- to high-penetrance breast cancer susceptibility genes, but it is unknown...
2.
Crouch D, Inshaw J, Robertson C, Ng E, Zhang J, Chen W, et al.
Genet Epidemiol
. 2025 Jan;
49(1):e22608.
PMID: 39749473
Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an...
3.
4.
Wang H, Concannon P, Ge Y
Genes Immun
. 2024 Nov;
26(1):54-62.
PMID: 39558087
The T cell Ubiquitin Ligand (TULA) protein family contains two members, UBASH3A and UBASH3B, that display similarities in protein sequence and domain structure. Both TULA proteins act to repress T...
5.
Sun X, Verma S, Jia G, Wang X, Ping J, Guo X, et al.
Cancer Res
. 2024 Jun;
84(15):2533-2548.
PMID: 38832928
Breast cancer includes several subtypes with distinct characteristic biological, pathologic, and clinical features. Elucidating subtype-specific genetic etiology could provide insights into the heterogeneity of breast cancer to facilitate the development...
6.
Sun X, Reiner A, Tran A, Watt G, Oh J, Mellemkjaer L, et al.
Breast Cancer Res
. 2024 Jan;
26(1):16.
PMID: 38263039
Background: Contralateral breast cancer (CBC) is the most common second primary cancer diagnosed in breast cancer survivors, yet the understanding of the genetic susceptibility of CBC, particularly with respect to...
7.
Newman J, Long S, Speake C, Greenbaum C, Cerosaletti K, Rich S, et al.
Commun Biol
. 2023 Sep;
6(1):988.
PMID: 37758901
Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting...
8.
Shapiro M, Dong X, Perry D, McNichols J, Thirawatananond P, Posgai A, et al.
JCI Insight
. 2023 Jul;
8(17).
PMID: 37498686
The proportions and phenotypes of immune cell subsets in peripheral blood undergo continual and dramatic remodeling throughout the human life span, which complicates efforts to identify disease-associated immune signatures in...
9.
Newman J, Concannon P, Ge Y
Int J Mol Sci
. 2023 May;
24(10).
PMID: 37240014
UBASH3A is a negative regulator of T cell activation and IL-2 production and plays key roles in autoimmunity. Although previous studies revealed the individual effects of UBASH3A on risk for...
10.
Perry D, Shapiro M, Chamberlain S, Kusmartseva I, Chamala S, Balzano-Nogueira L, et al.
Sci Data
. 2023 May;
10(1):323.
PMID: 37237059
The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest biorepository of human pancreata and associated immune organs from donors with type 1 diabetes (T1D), maturity-onset diabetes of...