Alpha 2.0
Login Register
» Authors » Patrick C Reading

Patrick C Reading

Explore the profile of Patrick C Reading including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 128
Citations 4784
Followers 0
Related Specialties
Allergy & Immunology
Microbiology
General Medicine
Top 10 Co-Authors
Andrew G Brooks
Sarah L Londrigan
Michelle D Tate
Emma R Job
Kirsty R Short
Katherine Kedzierska
Linda M Wakim
Geoffrey L Smith
Yi-Mo Deng
Fernando Villalon-Letelier
Published In
J Virol
J Immunol
J Gen Virol
PLoS One
Virology
Affiliations
Soon will be listed here.
Recent Articles
21.
Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling
Feng S, Enosi Tuipulotu D, Pandey A, Jing W, Shen C, Ngo C, et al.
Nat Commun . 2022 Jul; 13(1):4395. PMID: 35906252
Inflammasomes are cytosolic signaling complexes capable of sensing microbial ligands to trigger inflammation and cell death responses. Here, we show that guanylate-binding proteins (GBPs) mediate pathogen-selective inflammasome activation. We show...
22.
Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection
Schwab L, Villalon-Letelier F, Tessema M, Londrigan S, Brooks A, Hurt A, et al.
Viruses . 2022 Jul; 14(7). PMID: 35891527
RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies using human cells have demonstrated the ability of synthetic RIG-I agonists...
23.
Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution
Farrukee R, Gunalan V, Maurer-Stroh S, Reading P, Hurt A
J Virol . 2022 Jul; 96(15):e0091822. PMID: 35867563
Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These changes often come at a fitness cost; however, it is known that...
24.
Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection
Schwab L, Farrukee R, Eleouet J, Rameix-Welti M, Londrigan S, Brooks A, et al.
J Infect Dis . 2022 Jul; 226(12):2079-2088. PMID: 35861054
Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Treatment options are limited, and there is urgent need for the development of...
25.
Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression and Prevents Lesion Formation in the Mouse Zosteriform Model
Tessema M, Farrukee R, Andoniou C, Degli-Esposti M, Oates C, Barnes J, et al.
J Virol . 2022 May; 96(12):e0041922. PMID: 35638820
Myxovirus resistance (Mx) proteins are dynamin-like GTPases that are inducible by interferons (IFNs) following virus infections. Most studies investigating Mx proteins have focused on their activity against influenza A viruses...
26.
MARCH8 Restricts Influenza A Virus Infectivity but Does Not Downregulate Viral Glycoprotein Expression at the Surface of Infected Cells
Villalon-Letelier F, Brooks A, Londrigan S, Reading P
mBio . 2021 Sep; 12(5):e0148421. PMID: 34517760
Membrane-associated RING-CH8 (MARCH8) impairs the cell surface expression of envelope glycoproteins from different viruses, reducing their incorporation into virions. Using stable cell lines with inducible MARCH8 expression, we show that...
27.
IFITM Proteins That Restrict the Early Stages of Respiratory Virus Infection Do Not Influence Late-Stage Replication
Meischel T, Fritzlar S, Villalon-Letelier F, Tessema M, Brooks A, Reading P, et al.
J Virol . 2021 Jul; 95(20):e0083721. PMID: 34319159
Interferon-induced transmembrane (IFITM) proteins inhibit a broad range of enveloped viruses by blocking entry into host cells. We used an inducible overexpression system to investigate if IFITM1, IFITM2, and IFITM3...
28.
A second external quality assessment of isolation and identification of influenza viruses in cell culture in the Asia Pacific region highlights improved performance by participating laboratories
Leung V, Deng Y, Todd A, Peck H, Buettner I, Zakis T, et al.
J Clin Virol . 2021 Jul; 142:104907. PMID: 34274614
Influenza viruses must be amplified in cell culture for detailed antigenic analysis and for phenotypic assays assessing susceptibility to antiviral drugs or for other assays. Following on from the first...
29.
Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial
Chappell K, Mordant F, Li Z, Wijesundara D, Ellenberg P, Lackenby J, et al.
Lancet Infect Dis . 2021 Apr; 21(10):1383-1394. PMID: 33887208
Background: Given the scale of the ongoing COVID-19 pandemic, the development of vaccines based on different platforms is essential, particularly in light of emerging viral variants, the absence of information...
30.
Preclinical development of a molecular clamp-stabilised subunit vaccine for severe acute respiratory syndrome coronavirus 2
Watterson D, Wijesundara D, Modhiran N, Mordant F, Li Z, Avumegah M, et al.
Clin Transl Immunology . 2021 Apr; 10(4):e1269. PMID: 33841880
Objectives: Efforts to develop and deploy effective vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue at pace. Here, we describe rational antigen design through to manufacturability and vaccine...