Patrick A Forcelli
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Explore the profile of Patrick A Forcelli including associated specialties, affiliations and a list of published articles.
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109
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1708
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Recent Articles
1.
Gale K, Dybdal D, Wicker E, Campos-Rodriguez C, Maior R, Elorette C, et al.
Epilepsia
. 2024 Dec;
66(2):569-582.
PMID: 39636294
Objective: Area tempestas, a functionally defined region in the anterior piriform cortex, was identified as a crucial ictogenic trigger zone in the rat brain in the 1980s. However, whether the...
2.
Aguilar B, Toib J, Malkova L, Forcelli P
Behav Brain Res
. 2024 Oct;
477:115296.
PMID: 39426528
Rapidly approaching visual stimuli (i.e. looming objects) are known to evoke unconditioned defense responses across species. In rodents, this threat reactivity repertoire includes freezing and fleeing behavior. Although components of...
3.
Witherspoon E, Zuczek N, Williams G, Bernstein B, Ghosh A, Culjat M, et al.
Front Pediatr
. 2024 Oct;
12:1441891.
PMID: 39350791
Introduction: Exposure to a range of anti-seizure medications (ASMs) during early brain development adversely impacts neurodevelopmental outcomes in both animal models and in clinical studies. Many ASMs, including phenobarbital, phenytoin,...
4.
Hyder S, Lazarini-Lopes W, Toib J, Williams G, Sukharev A, Forcelli P
bioRxiv
. 2024 Sep;
PMID: 39345377
Engagement of the striatum (caudate/putamen) and other basal ganglia nuclei during seizures was first observed over 75 years ago. Basal ganglia output nuclei, and the substantia nigra pars reticulata, in...
5.
Khan T, McFall D, Hussain A, Frayser L, Casilli T, Steck M, et al.
bioRxiv
. 2024 Aug;
PMID: 39211239
Current therapies for the epilepsies only treat the symptoms, but do not prevent epileptogenesis (the process in which epilepsy develops). Many cellular responses during epileptogenesis are also common hallmarks of...
6.
Khan T, Hussain A, Casilli T, Frayser L, Cho M, Williams G, et al.
Aging Cell
. 2024 Jul;
23(9):e14239.
PMID: 39031751
Increased vulnerability to seizures in aging has been well documented both clinically and in various models of aging in epilepsy. Seizures can exacerbate cognitive decline that is already prominent in...
7.
Quinlan S, Witherspoon E, Forcelli P
Pharmacol Rep
. 2024 Jul;
76(5):1055-1066.
PMID: 39028384
Background: Padsevonil (PSL) is a rationally designed anti-seizure medication (ASM) which has overlapping mechanisms of action with the two most common ASMs used for neonatal seizures, phenobarbital (PB) and levetiracetam...
8.
Jacobs J, Maior R, Waguespack H, Campos-Rodriguez C, Malkova L, Forcelli P
Psychopharmacology (Berl)
. 2024 Jul;
242(1):101-115.
PMID: 39019996
Serotonin signaling plays critical roles in social and emotional behaviors. Likewise, decades of research demonstrate that the amygdala is a prime modulator of social behavior. Permanent excitotoxic lesions and transient...
9.
Witherspoon E, Williams G, Zuczek N, Forcelli P
Epilepsy Behav
. 2024 Jul;
158:109898.
PMID: 39002273
GABA modulators such as phenobarbital (PB) and sodium channel blockers such as phenytoin (PHT) have long been the mainstay of pharmacotherapy for the epilepsies. In the context of neonatal seizures,...
10.
Quinlan S, Khan T, McFall D, Campos-Rodriguez C, Forcelli P
Front Pharmacol
. 2024 Apr;
15:1340691.
PMID: 38606173
Phenobarbital (PB) and levetiracetam (LEV) are the first-line therapies for neonates with diagnosed seizures, however, a growing body of evidence shows that these drugs given during critical developmental windows trigger...