Patricia Winokur
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Explore the profile of Patricia Winokur including associated specialties, affiliations and a list of published articles.
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40
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734
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Recent Articles
1.
Reeder J, Creech C, Nation R, Gu K, Nalbant D, Wu N, et al.
J Clin Pharmacol
. 2024 Dec;
PMID: 39628093
Determining an effective dosing regimen for piperacillin-tazobactam in critically ill patients is challenging due to substantial pharmacokinetic variability caused by complex pathophysiological changes. To address this need, a prospective clinical...
2.
Rolsma S, Sokolow A, Patel P, Sokolow K, Jimenez-Truque N, Fissell W, et al.
J Infect Dis
. 2024 Sep;
231(2):e364-e374.
PMID: 39344185
Background: Patients with cystic fibrosis (CF) experience recurrent bacterial pulmonary exacerbations. Management of these infections is increasingly challenging due to decreased antimicrobial susceptibility to β-lactam antibiotics. The pharmacokinetics (PK) of...
3.
Rostad C, Atmar R, Walter E, Frey S, Meier J, Sherman A, et al.
Clin Infect Dis
. 2024 Mar;
78(6):1757-1768.
PMID: 38537255
Introduction: A surge of human influenza A(H7N9) cases began in 2016 in China from an antigenically distinct lineage. Data are needed about the safety and immunogenicity of 2013 and 2017...
4.
Rouphael N, Winokur P, Keefer M, Traenkner J, Drobeniuc A, Doi Y, et al.
mBio
. 2023 Sep;
14(5):e0167723.
PMID: 37698412
Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of...
5.
El Sahly H, Yildirim I, Frey S, Winokur P, Jackson L, Bernstein D, et al.
J Infect Dis
. 2023 Jul;
229(2):327-340.
PMID: 37466221
Background: Influenza A (H7N9) has caused multiple disease waves with evidence of strain diversification. Optimal influenza A (H7N9) prime-boost vaccine strategies are unknown. Methods: We recruited participants who had received...
6.
Branche A, Rouphael N, Diemert D, Falsey A, Losada C, Baden L, et al.
Res Sq
. 2023 May;
PMID: 37205592
Vaccine protection against COVID-19 wanes over time and has been impacted by the emergence of new variants with increasing escape of neutralization. The COVID-19 Variant Immunologic Landscape (COVAIL) randomized clinical...
7.
An G, Creech C, Wu N, Nation R, Gu K, Nalbant D, et al.
J Antimicrob Chemother
. 2023 Apr;
78(6):1460-1470.
PMID: 37071586
Objectives: We aimed to identify rational empirical dosing strategies for cefepime treatment in critically ill patients by utilizing population pharmacokinetics and target attainment analysis. Patients And Methods: A prospective and...
8.
Atmar R, Bernstein D, Winokur P, Frey S, Angelo L, Bryant C, et al.
Vaccine
. 2023 Mar;
41(16):2716-2722.
PMID: 36941155
Background: The continuing evolution of influenza viruses poses a challenge to vaccine prevention, highlighting the need for a universal influenza vaccine. We evaluated the safety and immunogenicity of one such...
9.
Winokur P, Gayed J, Fitz-Patrick D, Thomas S, Diya O, Lockhart S, et al.
N Engl J Med
. 2023 Jan;
388(3):214-227.
PMID: 36652353
Background: The emergence of immune-escape variants of severe acute respiratory syndrome coronavirus 2 warrants the use of sequence-adapted vaccines to provide protection against coronavirus disease 2019. Methods: In an ongoing...
10.
An G, Creech C, Wu N, Nation R, Gu K, Nalbant D, et al.
Antimicrob Agents Chemother
. 2023 Jan;
67(1):e0131222.
PMID: 36622154
In the present study, population pharmacokinetic (PK) analysis was performed based on meropenem data from a prospective study conducted in 114 critically ill patients with a wide range of renal...