Patricia McDonald
Overview
Explore the profile of Patricia McDonald including associated specialties, affiliations and a list of published articles.
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26
Citations
360
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Recent Articles
1.
Park M, Whelan C, Ahmed S, Boeringer T, Brown J, Crowder S, et al.
Cancers (Basel)
. 2024 Jul;
16(13).
PMID: 39001427
For many patients, the cancer continuum includes a syndrome known as cancer-associated cachexia (CAC), which encompasses the unintended loss of body weight and muscle mass, and is often associated with...
2.
Pierik L, McDonald P, Anderson A, West J
Bull Math Biol
. 2024 Mar;
86(5):47.
PMID: 38546759
Drug dose response curves are ubiquitous in cancer biology, but these curves are often used to measure differential response in first-order effects: the effectiveness of increasing the cumulative dose delivered....
3.
Maccioni P, Kaczanowska K, Lobina C, Regonini Somenzi L, Bassareo V, Gessa G, et al.
Alcohol
. 2023 Jul;
112:61-70.
PMID: 37495087
Recent studies have demonstrated the ability of the positive allosteric modulator (PAM) of the GABA receptor (GABA PAM), KK-92A, to suppress operant alcohol self-administration and reinstatement of alcohol seeking in...
4.
Maudsley S, Schrauwen C, Harputluoglu I, Walter D, Leysen H, McDonald P
Int J Mol Sci
. 2023 May;
24(10).
PMID: 37239845
G protein-coupled receptors (GPCRs) play a significant role in controlling biological paradigms such as aging and aging-related disease. We have previously identified receptor signaling systems that are specifically associated with...
5.
Maudsley S, Walter D, Schrauwen C, Van Loon N, Harputluoglu I, Lenaerts J, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362387
G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological process. They...
6.
Maccioni P, Kaczanowska K, McDonald P, Colombo G
Alcohol Alcohol
. 2022 May;
57(6):706-711.
PMID: 35589119
Aims: A recent study reported how acute treatment with KK-92A, a newly synthesized positive allosteric modulator (PAMs) of the GABAB receptor (GABAB PAMs), suppressed a series of alcohol-related behaviors, including...
7.
Pillai S, Mahmud I, Mahar R, Griffith C, Langsen M, Nguyen J, et al.
Cell Rep
. 2022 May;
39(6):110796.
PMID: 35545051
Malignant tumors exhibit altered metabolism resulting in a highly acidic extracellular microenvironment. Here, we show that cytoplasmic lipid droplet (LD) accumulation, indicative of a lipogenic phenotype, is a cellular adaption...
8.
Bailey T, Nieto A, McDonald P
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163825
Enlarged, hypertrophic adipocytes are less responsive to insulin and are a hallmark feature of obesity, contributing to many of the negative metabolic consequences of excess adipose tissue. Although the mechanisms...
9.
Maccioni P, Kaczanowska K, Lawrence H, Yun S, Bratzu J, Gessa G, et al.
Front Cell Dev Biol
. 2021 Nov;
9:727576.
PMID: 34778249
Positive allosteric modulators (PAMs) of the GABA receptor (GABA PAMs) are of interest in the addiction field due to their ability to suppress several behaviors motivated by drugs of abuse....
10.
Vena F, Bayle S, Nieto A, Quereda V, Aceti M, Frydman S, et al.
Mol Cancer Ther
. 2020 May;
19(8):1623-1635.
PMID: 32430484
Although gemcitabine is the cornerstone of care for pancreatic ductal adenocarcinoma (PDA), patients lack durable responses and relapse is inevitable. While the underlying mechanisms leading to gemcitabine resistance are likely...