Patricia G Tu
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Explore the profile of Patricia G Tu including associated specialties, affiliations and a list of published articles.
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9
Citations
509
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Recent Articles
1.
Ziegler Y, Moresco J, Tu P, Yates 3rd J, Nardulli A
Clin Proteomics
. 2018 Sep;
15:30.
PMID: 30250408
In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of personalized...
2.
Alessi A, Khivansara V, Han T, Freeberg M, Moresco J, Tu P, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
112(52):E7213-22.
PMID: 26669440
MicroRNAs (miRNAs) play essential, conserved roles in diverse developmental processes through association with the miRNA-induced silencing complex (miRISC). Whereas fundamental insights into the mechanistic framework of miRNA biogenesis and target...
3.
Ziegler Y, Moresco J, Tu P, Yates 3rd J, Nardulli A
PLoS One
. 2014 Jul;
9(7):e102341.
PMID: 25029196
The use of broad spectrum chemotherapeutic agents to treat breast cancer results in substantial and debilitating side effects, necessitating the development of targeted therapies to limit tumor proliferation and prevent...
4.
Fonslow B, Moresco J, Tu P, Aalto A, Pasquinelli A, Dillin A, et al.
WormBook
. 2014 Jun;
:1-18.
PMID: 24967700
Mass spectrometry (MS)-based shotgun proteomics is an enabling technology for the study of C. elegans proteins. When coupled with co-immunoprecipitation (CoIP), new interactions and functions among proteins can be discovered....
5.
Kallgren S, Andrews S, Tadeo X, Hou H, Moresco J, Tu P, et al.
PLoS Genet
. 2014 May;
10(5):e1004334.
PMID: 24874881
Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation. The RNAi machinery is required for heterochromatin assembly in a diverse range of...
6.
Yao C, Choi E, Weng L, Xie X, Wan J, Xing Y, et al.
RNA
. 2013 Oct;
19(12):1781-90.
PMID: 24149845
mRNA 3' processing is dynamically regulated spatially and temporally. However, the underlying mechanisms remain poorly understood. CstF64τ is a paralog of the general mRNA 3' processing factor, CstF64, and has...
7.
Wang J, Tadeo X, Hou H, Tu P, Thompson J, Yates 3rd J, et al.
Genes Dev
. 2013 Sep;
27(17):1886-902.
PMID: 24013502
Heterochromatin spreading leads to the silencing of genes within its path, and boundary elements have evolved to constrain such spreading. In fission yeast, heterochromatin at centromeres I and III is...
8.
Shoulders M, Ryno L, Genereux J, Moresco J, Tu P, Wu C, et al.
Cell Rep
. 2013 Apr;
3(4):1279-92.
PMID: 23583182
The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6. The functional consequences of these transcription factors for ER...
9.
Ambatipudi K, Swatkoski S, Moresco J, Tu P, Coca A, Anolik J, et al.
Proteomics
. 2012 Aug;
12(19-20):3113-20.
PMID: 22888089
The diagnosis of primary Sjögren's syndrome (pSS) is difficult due to the lack of specific laboratory and clinical tests. As an initial step for the global discovery of changes in...