Patricia Fontan
Overview
Explore the profile of Patricia Fontan including associated specialties, affiliations and a list of published articles.
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5
Citations
328
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Recent Articles
1.
Nesbitt N, Yang X, Fontan P, Kolesnikova I, Smith I, Sampson N, et al.
Infect Immun
. 2009 Oct;
78(1):275-82.
PMID: 19822655
Mycobacterium tuberculosis, the causative agent of tuberculosis, is an intracellular pathogen that shifts to a lipid-based metabolism in the host. Moreover, metabolism of the host lipid cholesterol plays an important...
2.
Global transcriptional profile of Mycobacterium tuberculosis during THP-1 human macrophage infection
Fontan P, Aris V, Ghanny S, Soteropoulos P, Smith I
Infect Immun
. 2007 Dec;
76(2):717-25.
PMID: 18070897
During lung infection, Mycobacterium tuberculosis resides in macrophages and subverts the bactericidal mechanisms of these professional phagocytes. Comprehension of this host-pathogen relationship is fundamental for the development of new therapies...
3.
Rehren G, Walters S, Fontan P, Smith I, Zarraga A
Tuberculosis (Edinb)
. 2007 Apr;
87(4):347-59.
PMID: 17433778
The high sequence identity among the Mycobacterium bovis and Mycobacterium tuberculosis genomes contrasts with the physiological differences reported between these pathogens, suggesting that variations in gene expression may be involved....
4.
Pancholi V, Fontan P, Jin H
Microb Pathog
. 2003 Oct;
35(6):293-303.
PMID: 14580393
Alpha-enolase (SEN) is a strong plasminogen-binding protein on the surface of group A streptococci (GAS). By flow cytometry and immunofluorescence analyses and using human enolase-specific antibody, human pharyngeal cells (Detroit...
5.
Dubnau E, Fontan P, Manganelli R, Smith I
Infect Immun
. 2002 May;
70(6):2787-95.
PMID: 12010964
We identified Mycobacterium tuberculosis genes preferentially expressed during infection of human macrophages using a promoter trap adapted for this pathogen. inhA encodes an enoyl-acyl carrier protein reductase that is required...