Patricia A DiGiuseppe Champion
Overview
Explore the profile of Patricia A DiGiuseppe Champion including associated specialties, affiliations and a list of published articles.
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14
Citations
995
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Recent Articles
1.
Johnson B, Colvin C, Needle D, Mba Medie F, Champion P, Abramovitch R
Antimicrob Agents Chemother
. 2015 May;
59(8):4436-45.
PMID: 25987613
Mycobacterium tuberculosis must sense and adapt to host environmental cues to establish and maintain an infection. The two-component regulatory system PhoPR plays a central role in sensing and responding to...
2.
Zhao Y, Riley N, Sun L, Hebert A, Yan X, Westphall M, et al.
Anal Chem
. 2015 Apr;
87(10):5422-9.
PMID: 25893372
Top-down proteomics offers the potential for full protein characterization, but many challenges remain for this approach, including efficient protein separations and effective fragmentation of intact proteins. Capillary zone electrophoresis (CZE)...
3.
Mba Medie F, Champion M, Williams E, Champion P
Infect Immun
. 2014 Aug;
82(11):4572-86.
PMID: 25135684
The mycobacterial Esx-1 (ESAT-6 system 1) exporter translocates virulence factors across the cytoplasmic membrane to the cell wall, cell surface, and the bacteriological medium in vitro. The mechanisms underlying substrate...
4.
Champion M, Williams E, Pinapati R, Champion P
J Proteome Res
. 2014 Aug;
13(11):5151-64.
PMID: 25106450
The Esx/WXG-100 (ESAT-6/Wss) exporters are multiprotein complexes that promote protein translocation across the cytoplasmic membrane in a diverse range of pathogenic and nonpathogenic bacterial species. The Esx-1 (ESAT-6 System-1) system...
5.
Kennedy G, Hooley G, Champion M, Mba Medie F, Champion P
J Bacteriol
. 2014 Mar;
196(10):1877-88.
PMID: 24610712
EsxA (ESAT-6) and EsxB (CFP-10) are virulence factors exported by the ESX-1 system in mycobacterial pathogens. In Mycobacterium marinum, an established model for ESX-1 secretion in Mycobacterium tuberculosis, genes required...
6.
7.
Champion M, Williams E, Kennedy G, Champion P
Mol Cell Proteomics
. 2012 May;
11(9):596-604.
PMID: 22580590
Bacteria use a variety of secretion systems to transport proteins beyond their cell membrane to interact with their environment. For bacterial pathogens, these systems are key virulence determinants that transport...
8.
Kennedy G, Morisaki J, Champion P
Appl Environ Microbiol
. 2012 Jan;
78(6):2049-52.
PMID: 22247144
Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for...
9.
Li Y, Champion M, Sun L, Champion P, Wojcik R, Dovichi N
Anal Chem
. 2011 Dec;
84(3):1617-22.
PMID: 22182061
We demonstrate the use of capillary zone electrophoresis with an electrokinetically pumped sheath-flow electrospray interface for the analysis of a tryptic digest of a sample of intermediate protein complexity, the...
10.
Shiloh M, Champion P
Curr Opin Microbiol
. 2009 Dec;
13(1):86-92.
PMID: 20036184
Mycobacterium tuberculosis is the causative agent of the global tuberculosis epidemic. To combat this successful human pathogen we need a better understanding of the basic biology of mycobacterial pathogenesis. The...