Pasi Soininen
Overview
Explore the profile of Pasi Soininen including associated specialties, affiliations and a list of published articles.
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134
Citations
8488
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Recent Articles
1.
Julkunen H, Cichonska A, Tiainen M, Koskela H, Nybo K, Makela V, et al.
Nat Commun
. 2023 Feb;
14(1):604.
PMID: 36737450
Blood lipids and metabolites are markers of current health and future disease risk. Here, we describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 participants in the UK Biobank....
2.
Auvinen J, Tapio J, Karhunen V, Kettunen J, Serpi R, Dimova E, et al.
Sci Adv
. 2021 Jul;
7(29).
PMID: 34261659
Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored...
3.
4.
Jaaskelainen O, Hall A, Tiainen M, van Gils M, Lotjonen J, Kangas A, et al.
J Alzheimers Dis
. 2020 Feb;
74(1):277-286.
PMID: 32007958
Accurate differentiation between neurodegenerative diseases is developing quickly and has reached an effective level in disease recognition. However, there has been less focus on effectively distinguishing the prodromal state from...
5.
Jaaskelainen O, Solje E, Hall A, Katisko K, Korhonen V, Tiainen M, et al.
J Alzheimers Dis
. 2019 Sep;
72(1):127-137.
PMID: 31561355
Decreased levels of serum high-density lipoprotein (HDL) cholesterol have previously been linked to systemic inflammation and neurodegenerative diseases, such as Alzheimer's disease. Here, we aimed to analyze the lipoprotein profile...
6.
Mannisto V, Kaminska D, Karja V, Tiainen M, de Mello V, Hanhineva K, et al.
Liver Int
. 2019 Jun;
39(10):1895-1905.
PMID: 31199045
Background & Aims: Alterations in liver phosphatidylcholine (PC) metabolism have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Although genetic variation in the phosphatidylethanolamine N-methyltransferase (PEMT) enzyme...
7.
Akbaraly T, Wurtz P, Singh-Manoux A, Shipley M, Haapakoski R, Lehto M, et al.
Sci Rep
. 2018 Jun;
8(1):8620.
PMID: 29872056
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations - the Alternative Healthy...
8.
Sliz E, Sebert S, Wurtz P, Kangas A, Soininen P, Lehtimaki T, et al.
Hum Mol Genet
. 2018 Apr;
27(12):2214-2223.
PMID: 29648650
Fatty liver has been associated with unfavourable metabolic changes in circulation. To provide insights in fatty liver-related metabolic deviations, we compared metabolic association profile of fatty liver versus metabolic association...
9.
Tynkkynen J, Chouraki V, van der Lee S, Hernesniemi J, Yang Q, Li S, et al.
Alzheimers Dement
. 2018 Mar;
14(6):723-733.
PMID: 29519576
Introduction: Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into mechanisms underlying incident dementia and Alzheimer's disease. Methods: We studied eight prospective cohorts with 22,623 participants profiled by...
10.
Teslovich T, Kim D, Yin X, Stancakova A, Jackson A, Wielscher M, et al.
Hum Mol Genet
. 2018 Feb;
27(9):1664-1674.
PMID: 29481666
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino...