Parag Mahanti
Overview
Explore the profile of Parag Mahanti including associated specialties, affiliations and a list of published articles.
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9
Citations
610
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Recent Articles
1.
Panda O, Akagi A, Artyukhin A, Judkins J, Le H, Mahanti P, et al.
Angew Chem Int Ed Engl
. 2017 Apr;
56(17):4729-4733.
PMID: 28371259
The nematode Caenorhabditis elegans uses simple building blocks from primary metabolism and a strategy of modular assembly to build a great diversity of signaling molecules, the ascarosides, which function as...
2.
Meisel J, Panda O, Mahanti P, Schroeder F, Kim D
Cell
. 2014 Oct;
159(2):267-80.
PMID: 25303524
Discrimination between pathogenic and beneficial microbes is essential for host organism immunity and homeostasis. Here, we show that chemosensory detection of two secondary metabolites produced by Pseudomonas aeruginosa modulates a...
3.
Judkins J, Mahanti P, Hoffman J, Yim I, Antebi A, Schroeder F
Angew Chem Int Ed Engl
. 2014 Jan;
53(8):2110-3.
PMID: 24453122
The development and lifespan of C. elegans are controlled by the nuclear hormone receptor DAF-12, an important model for the vertebrate vitamin D and liver X receptors. As with its...
4.
Mahanti P, Bose N, Bethke A, Judkins J, Wollam J, Dumas K, et al.
Cell Metab
. 2014 Jan;
19(1):73-83.
PMID: 24411940
Small-molecule ligands of nuclear hormone receptors (NHRs) govern the transcriptional regulation of metazoan development, cell differentiation, and metabolism. However, the physiological ligands of many NHRs remain poorly characterized, primarily due...
5.
Coburn C, Allman E, Mahanti P, Benedetto A, Cabreiro F, Pincus Z, et al.
PLoS Biol
. 2013 Aug;
11(7):e1001613.
PMID: 23935448
For cells the passage from life to death can involve a regulated, programmed transition. In contrast to cell death, the mechanisms of systemic collapse underlying organismal death remain poorly understood....
6.
Ludewig A, Izrayelit Y, Park D, Malik R, Zimmermann A, Mahanti P, et al.
Proc Natl Acad Sci U S A
. 2013 Mar;
110(14):5522-7.
PMID: 23509272
Lifespan in Caenorhabditis elegans, Drosophila, and mice is regulated by conserved signaling networks, including the insulin/insulin-like growth factor 1 (IGF-1) signaling cascade and pathways depending on sirtuins, a family of...
7.
Hsueh Y, Mahanti P, Schroeder F, Sternberg P
Curr Biol
. 2012 Dec;
23(1):83-6.
PMID: 23246407
The recognition of molecular patterns associated with specific pathogens or food sources is fundamental to ecology and plays a major role in the evolution of predator-prey relationships. Recent studies showed...
8.
Srinivasan J, Von Reuss S, Bose N, Zaslaver A, Mahanti P, Ho M, et al.
PLoS Biol
. 2012 Jan;
10(1):e1001237.
PMID: 22253572
The nematode C. elegans is an important model for the study of social behaviors. Recent investigations have shown that a family of small molecule signals, the ascarosides, controls population density...
9.
Kaplan F, Srinivasan J, Mahanti P, Ajredini R, Durak O, Nimalendran R, et al.
PLoS One
. 2011 Mar;
6(3):e17804.
PMID: 21423575
Background: The ascarosides form a family of small molecules that have been isolated from cultures of the nematode Caenorhabditis elegans. They are often referred to as "dauer pheromones" because most...