Paolo E Porporato
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Explore the profile of Paolo E Porporato including associated specialties, affiliations and a list of published articles.
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Articles
59
Citations
2781
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Recent Articles
1.
Kramer-Drauberg M, Petrini E, Mira A, Patrucco E, Scardaci R, Savinelli I, et al.
Mol Oncol
. 2025 Jan;
19(2):311-328.
PMID: 39838816
Specific reactive oxygen species activate the GTPase Kirsten rat sarcoma virus (KRAS) by reacting with cysteine 118 (C118), leading to an electron transfer between C118 and nucleoside guanosine diphosphate (GDP),...
2.
Wyart E, Carra G, Angelino E, Penna F, Porporato P
Trends Endocrinol Metab
. 2025 Jan;
PMID: 39757061
Cachexia is a complex metabolic disorder characterized by negative energy balance due to increased consumption and lowered intake, leading to progressive tissue wasting and inefficient energy distribution. Once considered as...
3.
Mina E, Wyart E, Sartori R, Angelino E, Zaggia I, Rausch V, et al.
Cell Rep Med
. 2023 Dec;
4(12):101306.
PMID: 38052214
Skeletal muscle atrophy is a hallmark of cachexia, a wasting condition typical of chronic pathologies, that still represents an unmet medical need. Bone morphogenetic protein (BMP)-Smad1/5/8 signaling alterations are emerging...
4.
Rossi A, Asthana A, Riganti C, Sedrakyan S, Byers L, Robertson J, et al.
Ann Surg
. 2023 Jul;
278(6):e1313-e1326.
PMID: 37450698
Objectives: To test whether mitochondrial transplantation (MITO) mitigates damage in 2 models of acute kidney injury (AKI). Background: MITO is a process where exogenous isolated mitochondria are taken up by...
5.
Beltra M, Pollanen N, Fornelli C, Tonttila K, Hsu M, Zampieri S, et al.
Nat Commun
. 2023 Apr;
14(1):1849.
PMID: 37012289
Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicotinamide...
6.
Capeloa T, Van de Velde J, dHose D, Lipari S, Derouane F, Hamelin L, et al.
Cancers (Basel)
. 2022 Oct;
14(19).
PMID: 36230841
At diagnosis, about 35% of pancreatic cancers are at the locally invasive yet premetastatic stage. Surgical resection is not a treatment option, leaving patients with a largely incurable disease that...
7.
Capeloa T, Krzystyniak J, dHose D, Canas Rodriguez A, Payen V, Zampieri L, et al.
Cancers (Basel)
. 2022 Mar;
14(6).
PMID: 35326667
To successfully generate distant metastases, metastatic progenitor cells must simultaneously possess mesenchymal characteristics, resist to anoïkis, migrate and invade directionally, resist to redox and shear stresses in the systemic circulation,...
8.
Capeloa T, Krzystyniak J, Canas Rodriguez A, Payen V, Zampieri L, Pranzini E, et al.
Cancers (Basel)
. 2022 Mar;
14(6).
PMID: 35326639
In oncology, the occurrence of distant metastases often marks the transition from curative to palliative care. Such outcome is highly predictable for breast cancer patients, even if tumors are detected...
9.
Wyart E, Hsu M, Sartori R, Mina E, Rausch V, Pierobon E, et al.
EMBO Rep
. 2022 Feb;
23(4):e53746.
PMID: 35199910
Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%....
10.
Thibaut M, Sboarina M, Roumain M, Potgens S, Neyrinck A, Destree F, et al.
J Cachexia Sarcopenia Muscle
. 2020 Dec;
12(1):70-90.
PMID: 33350058
Background: Cancer cachexia is a debilitating metabolic syndrome contributing to cancer death. Organs other than the muscle may contribute to the pathogenesis of cancer cachexia. This work explores new mechanisms...