Panduka Nagahawatte
Overview
Explore the profile of Panduka Nagahawatte including associated specialties, affiliations and a list of published articles.
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11
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2960
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Recent Articles
1.
Nagahawatte P, Willis E, Sakauye M, Jose R, Chen H, Davis R
Exp Biol Med (Maywood)
. 2016 Feb;
241(11):1202-9.
PMID: 26900164
We present an article viewer application that allows a scientific reader to easily discover and share knowledge by linking genomics-related concepts to knowledge of disparate biomedical databases. High-throughput data streams...
2.
Ma X, Edmonson M, Yergeau D, Muzny D, Hampton O, Rusch M, et al.
Nat Commun
. 2015 Mar;
6:6604.
PMID: 25790293
There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute...
3.
Andersson A, Ma J, Wang J, Chen X, Gedman A, Dang J, et al.
Nat Genet
. 2015 Mar;
47(4):330-7.
PMID: 25730765
Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis. To define its mutational landscape, we performed whole-genome, exome, RNA and targeted DNA...
4.
Lu C, Zhang J, Nagahawatte P, Easton J, Lee S, Liu Z, et al.
J Invest Dermatol
. 2014 Oct;
135(3):816-823.
PMID: 25268584
Despite remarkable advances in the genomic characterization of adult melanoma, the molecular pathogenesis of pediatric melanoma remains largely unknown. We analyzed 15 conventional melanomas (CMs), 3 melanomas arising in congenital...
5.
Roberts K, Li Y, Payne-Turner D, Harvey R, Yang Y, Pei D, et al.
N Engl J Med
. 2014 Sep;
371(11):1005-15.
PMID: 25207766
Background: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome....
6.
Wu G, Diaz A, Paugh B, Rankin S, Ju B, Li Y, et al.
Nat Genet
. 2014 Apr;
46(5):444-450.
PMID: 24705251
Pediatric high-grade glioma (HGG) is a devastating disease with a less than 20% survival rate 2 years after diagnosis. We analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs)...
7.
Chen X, Bahrami A, Pappo A, Easton J, Dalton J, Hedlund E, et al.
Cell Rep
. 2014 Apr;
7(1):104-12.
PMID: 24703847
Pediatric osteosarcoma is characterized by multiple somatic chromosomal lesions, including structural variations (SVs) and copy number alterations (CNAs). To define the landscape of somatic mutations in pediatric osteosarcoma, we performed...
8.
McEvoy J, Nagahawatte P, Finkelstein D, Richards-Yutz J, Valentine M, Ma J, et al.
Oncotarget
. 2014 Feb;
5(2):438-50.
PMID: 24509483
Retinoblastoma is a rare childhood cancer of the developing retina. Most retinoblastomas initiate with biallelic inactivation of the RB1 gene through diverse mechanisms including point mutations, nucleotide insertions, deletions, loss...
9.
Chen X, Stewart E, Shelat A, Qu C, Bahrami A, Hatley M, et al.
Cancer Cell
. 2013 Dec;
24(6):710-24.
PMID: 24332040
Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic...
10.
A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia
Shah S, Schrader K, Waanders E, Timms A, Vijai J, Miething C, et al.
Nat Genet
. 2013 Sep;
45(10):1226-1231.
PMID: 24013638
Somatic alterations of the lymphoid transcription factor gene PAX5 (also known as BSAP) are a hallmark of B cell precursor acute lymphoblastic leukemia (B-ALL), but inherited mutations of PAX5 have...