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Pamela Tran

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Citations 47
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Recent Articles
1.
Stottmann R, Turbe-Doan A, Tran P, Kratz L, Moran J, Kelley R, et al.
PLoS Genet . 2011 Sep; 7(9):e1002224. PMID: 21912524
We describe the rudolph mouse, a mutant with striking defects in both central nervous system and skeletal development. Rudolph is an allele of the cholesterol biosynthetic enzyme, hydroxysteroid (17-beta) dehydrogenase...
2.
Pickell L, Tran P, Leclerc D, Hiscott J, Rozen R
Biochim Biophys Acta . 2005 Nov; 1731(2):104-14. PMID: 16274753
Two promoters of the murine methylenetetrahydrofolate reductase gene (Mthfr), a key enzyme in folate metabolism, were characterized in Neuro-2a, NIH/3T3 and RAW 264.7 cells. Sequences of 189 bp and 273...
3.
Tran P, Leclerc D, Chan M, Pai A, Hiou-Tim F, Wu Q, et al.
Mamm Genome . 2002 Oct; 13(9):483-92. PMID: 12370778
Methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the major carbon donor in the remethylation of homocysteine to methionine. Mild MTHFR deficiency, due to a common variant at nucleotide 677, has...
4.
Tran P, Hiou-Tim F, Frosst P, Lussier-Cacan S, Bagley P, Selhub J, et al.
Mol Genet Metab . 2002 Sep; 76(4):297-304. PMID: 12208134
Maternal mild hyperhomocysteinemia is associated with increased risk for bearing children with neural tube defects (NTD). Folate intake corrects hyperhomocysteinemia and prevents up to 70% of NTD. The curly-tail (ct)...