Pamela Gerenser
Overview
Explore the profile of Pamela Gerenser including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
27
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Recent Articles
1.
Morissette P, Li N, Ballard J, Vavrek M, Adams G, Regan C, et al.
Toxicol Sci
. 2021 Dec;
185(2):170-183.
PMID: 34897513
Studies have shown that some peptides and small molecules can induce non IgE-mediated anaphylactoid reactions through mast cell activation. Upon activation, mast cells degranulate and release vasoactive and proinflammatory mediators,...
2.
Regan C, Morissette P, Regan H, Travis J, Gerenser P, Wen J, et al.
Hepatology
. 2016 Jul;
64(5):1430-1441.
PMID: 27474787
Conclusions: These are the first preclinical in vivo experiments reported to replicate the severe clinical SOF+AMIO cardiac DDI and provide potential in vivo mechanism of action. As such, these data...
3.
Morissette P, Regan H, FitzGerald K, Bernasconi S, Gerenser P, Travis J, et al.
J Pharmacol Toxicol Methods
. 2015 May;
75:52-61.
PMID: 26001325
Introduction: The anesthetized guinea pig (ANES GP) has proven to be an effective small animal model to evaluate cardiac electrophysiologic effects of drug-candidate molecules during lead optimization. While heart rate...
4.
The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model
Morissette P, Nishida M, Trepakova E, Imredy J, Lagrutta A, Chaves A, et al.
J Pharmacol Toxicol Methods
. 2013 May;
68(1):137-49.
PMID: 23649000
Introduction: In recent years, the anesthetized guinea pig has been used increasingly to evaluate the cardiovascular effects of drug-candidate molecules during lead optimization prior to conducting longer, more resource intensive...