Paivi Saavalainen
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Explore the profile of Paivi Saavalainen including associated specialties, affiliations and a list of published articles.
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Articles
82
Citations
1817
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Recent Articles
1.
Nissila E, Starck L, Aho E, Venerandi E, Jalkanen P, Leskinen K, et al.
Scand J Immunol
. 2025 Jan;
101(2):e70000.
PMID: 39891027
The ChAdOx1 nCoV-19 vaccine has been in large-scale use during the COVID-19 pandemic. Limited efficacy compared to mRNA vaccines and certain potential side effects raise the question of whether anti-adenoviral...
2.
Turpin R, Liu R, Munne P, Peura A, Rannikko J, Philips G, et al.
J Immunother Cancer
. 2024 Apr;
12(4).
PMID: 38604809
Background: Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore,...
3.
Elomaa P, Ojalehto T, Kumar D, Jokinen V, Saavalainen P
Biomicrofluidics
. 2024 Feb;
18(1):014106.
PMID: 38420041
Droplet digital PCR (ddPCR) is a technique in which PCR reaction is divided into thousands of nanoliter-sized droplets and has proven to be a great tool in virus diagnostics. Compared...
4.
Chernyaeva L, Ratti G, Teirila L, Fudo S, Rankka U, Pelkonen A, et al.
EMBO Rep
. 2023 May;
24(7):e56467.
PMID: 37155564
The APOE4 variant of apolipoprotein E (apoE) is the most prevalent genetic risk allele associated with late-onset Alzheimer's disease (AD). ApoE interacts with complement regulator factor H (FH), but the...
5.
Freitag T, Fagerlund R, Karam N, Leppanen V, Ugurlu H, Kant R, et al.
Vaccine
. 2023 Apr;
41(20):3233-3246.
PMID: 37085458
The ongoing SARS-CoV-2 pandemic is controlled but not halted by public health measures and mass vaccination strategies which have exclusively relied on intramuscular vaccines. Intranasal vaccines can prime or recruit...
6.
Jonkergouw C, Beyeh N, Osmekhina E, Leskinen K, Taimoory S, Fedorov D, et al.
Nat Commun
. 2023 Apr;
14(1):2141.
PMID: 37059703
The limited diversity in targets of available antibiotic therapies has put tremendous pressure on the treatment of bacterial pathogens, where numerous resistance mechanisms that counteract their function are becoming increasingly...
7.
Barmaki S, Al-Samadi A, Leskinen K, Wahbi W, Jokinen V, Vuoristo S, et al.
Biomater Biosyst
. 2023 Feb;
7:100056.
PMID: 36824489
Oxygen tension varies during placental and fetal development. Although hypoxia drives early trophoblast invasion, low placental oxygen levels during pregnancy show association with pregnancy complications including fetal growth restriction and...
8.
Johansson T, Partanen J, Saavalainen P
Front Immunol
. 2022 Oct;
13:1007425.
PMID: 36248878
Varying HLA allele-specific expression levels are associated with human diseases, such as graft versus host disease (GvHD) in hematopoietic stem cell transplantation (HSCT), cytotoxic T cell response and viral load...
9.
Virta J, Hannula M, Lindfors K, Tamminen I, Taavela J, Huhtala H, et al.
Front Immunol
. 2022 Oct;
13:945197.
PMID: 36211435
Background: Duodenal histology remains the diagnostic reference standard in celiac disease. However, traditional methods have suboptimal sensitivity and reproducibility for early mucosal changes and research purposes. We validated a recently...
10.
Eberl A, Qadri S, Saavalainen P, Sipponen T
Eur J Gastroenterol Hepatol
. 2022 Sep;
34(11):1125-1131.
PMID: 36170681
Objective: Measuring of serum infliximab (IFX) induction concentrations might reduce primary non-response rates in inflammatory bowel diseases (IBD), but optimal target concentrations are unclear. We investigated whether IFX induction concentrations...