Pablo Lara-Gonzalez
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Explore the profile of Pablo Lara-Gonzalez including associated specialties, affiliations and a list of published articles.
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1047
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Recent Articles
1.
Schlientz A, Lee K, Sebastian Gomez-Cavazos J, Lara-Gonzalez P, Desai A, Oegema K
bioRxiv
. 2024 Nov;
PMID: 39554051
During cytokinesis, an equatorial contractile ring partitions the cell contents. Contractile ring assembly requires an equatorial zone of active GTP-bound RhoA generated by the guanine nucleotide exchange factor ECT2. ECT2...
2.
Lara-Gonzalez P, Variyar S, Moghareh S, Nguyen A, Kizhedathu A, Budrewicz J, et al.
J Cell Biol
. 2024 Aug;
223(11).
PMID: 39105756
Mitosis in early embryos often proceeds at a rapid pace, but how this pace is achieved is not understood. Here, we show that cyclin B3 is the dominant driver of...
3.
Phospho-KNL-1 recognition by a TPR domain targets the BUB-1-BUB-3 complex to C. elegans kinetochores
Houston J, Vissotsky C, Deep A, Hakozaki H, Crews E, Oegema K, et al.
J Cell Biol
. 2024 Apr;
223(7).
PMID: 38578284
During mitosis, the Bub1-Bub3 complex concentrates at kinetochores, the microtubule-coupling interfaces on chromosomes, where it contributes to spindle checkpoint activation, kinetochore-spindle microtubule interactions, and protection of centromeric cohesion. Bub1 has...
4.
Houston J, Vissotsky C, Deep A, Hakozaki H, Crews E, Oegema K, et al.
bioRxiv
. 2024 Feb;
PMID: 38370671
During mitosis, the Bub1-Bub3 complex concentrates at kinetochores, the microtubule-coupling interfaces on chromosomes, where it contributes to spindle checkpoint activation, kinetochore-spindle microtubule interactions, and protection of centromeric cohesion. Bub1 has...
5.
Lara-Gonzalez P, Variyar S, Budrewicz J, Schlientz A, Varshney N, Bellaart A, et al.
bioRxiv
. 2023 Aug;
PMID: 37609212
In many species, early embryonic mitoses proceed at a very rapid pace, but how this pace is achieved is not understood. Here we show that in the early embryo, cyclin...
6.
Houston J, Ohta M, Sebastian Gomez-Cavazos J, Deep A, Corbett K, Oegema K, et al.
Curr Biol
. 2023 May;
33(11):2291-2299.e10.
PMID: 37137308
During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle microtubules. Kinetochores also function as signaling hubs directing mitotic progression by recruiting and controlling the fate of the anaphase promoting...
7.
Rocha H, Simoes P, Budrewicz J, Lara-Gonzalez P, Carvalho A, Dumont J, et al.
J Cell Biol
. 2023 Jan;
222(3).
PMID: 36719399
A landmark event in the transition from interphase to mitosis in metazoans is nuclear envelope breakdown (NEBD). Important mitotic events occur prior to NEBD, including condensation of replicated chromosomes and...
8.
Wang L, Heffner C, Vong K, Barrows C, Ha Y, Lee S, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(4):e2209983120.
PMID: 36669109
encodes an evolutionarily conserved widely expressed novel 8-pass transmembrane protein of unknown function in human. Here we identify homozygous hypomorphic missense variants in our recessive polymicrogyria (PMG) cohort. Patients carrying...
9.
Ferguson C, Urso O, Bodrug T, Gassaway B, Watson E, Prabu J, et al.
Mol Cell
. 2021 Dec;
82(1):90-105.e13.
PMID: 34942119
Neurodevelopmental cognitive disorders provide insights into mechanisms of human brain development. Here, we report an intellectual disability syndrome caused by the loss of APC7, a core component of the E3...
10.
Lara-Gonzalez P, Pines J, Desai A
Semin Cell Dev Biol
. 2021 Jul;
117:86-98.
PMID: 34210579
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto...