P Sipkema
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Explore the profile of P Sipkema including associated specialties, affiliations and a list of published articles.
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88
Citations
808
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Recent Articles
11.
Yamamoto S, Sipkema P, Yin F
Heart Vessels
. 1999 Oct;
14(1):9-14.
PMID: 10543309
We previously showed that deformation of the cardiac tissue surrounding a dilated coronary artery changes its hydraulic resistance depending on the direction of stretch. Stretch parallel, but not perpendicular, to...
12.
Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries
Kerkhof C, Bakker E, Sipkema P
Am J Physiol
. 1999 Oct;
277(4):H1546-52.
PMID: 10516194
The role of arachidonic acid metabolism and nitric oxide (NO) in hypoxia-induced changes of vascular tone was investigated in first-order cannulated rat cremaster muscle resistance arteries. Spontaneous tone reduced arterial...
13.
Bakker E, Kerkhof C, Sipkema P
Cardiovasc Res
. 1999 May;
41(1):229-36.
PMID: 10325970
Objective: The mechanism of spontaneous myogenic tone was investigated in isolated arteriolar segments. Methods: Arterioles were isolated from rat cremaster muscle. Segments were endothelium-denuded and mounted in a pressure myograph...
14.
Boer C, Scheffer G, de Lange J, Westerhof N, Sipkema P
J Vasc Res
. 1999 Mar;
36(1):79-81.
PMID: 10050076
No abstract available.
15.
Braakman R, Van Der Linden P, Sipkema P
Invest Ophthalmol Vis Sci
. 1999 Feb;
40(2):370-7.
PMID: 9950595
Purpose: Based on diameter measurements on the short posterior ciliary artery, this study was intended to determine the direct pharmacologic effect of beta-blockers; to determine the differences among a selective...
16.
Sipkema P, Takkenberg J, Zeeuwe P, Westerhof N
Cardiovasc Res
. 1999 Jan;
40(1):88-95.
PMID: 9876320
Objective: To study the effect of cardiac contraction on left coronary artery pressure-flow relations at different vascular volumes and to compare these relations in the beating heart with those in...
17.
Bakker E, Sipkema P
Cardiovasc Res
. 1998 Sep;
38(3):782-7.
PMID: 9747447
Objective: Prostaglandins and nitric oxide play an important role in the regulation of arteriolar tone. L-Arginine analogues inhibit nitric oxide formation, but may also inhibit arachidonic-acid induced dilation. Nitric oxide...
18.
Dijkman M, Heslinga J, Sipkema P, Westerhof N
Am J Physiol
. 1998 Mar;
274(2):H405-10.
PMID: 9486241
The perfusion-induced increase in cardiac contractility (Gregg phenomenon) is especially found in heart preparations that lack adequate coronary autoregulation and thus protection of changes in capillary pressure. We determined in...
19.
Bakker E, Van der Linden P, Sipkema P
J Vasc Res
. 1998 Jan;
34(6):418-24.
PMID: 9425994
Vascular endothelial cells release dilatory compounds like nitric oxide and prostacyclin, as well as contractile factors like endothelin-1 (ET-1). We investigated the interaction of ET-1 with nitric-oxide-mediated dilation in cannulated...
20.
Bakker E, Sipkema P
Am J Physiol
. 1997 Nov;
273(4):H1848-53.
PMID: 9362252
Acetylcholine-induced dilation was studied in cannulated resistance arteries of rat cremaster muscle. Pressurized arteriolar segments (internal diameter: 175 +/- 2 microm) developed spontaneous tone (90 +/- 2 microm). Application of...