P Roughley
Overview
Explore the profile of P Roughley including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
583
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0
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Recent Articles
1.
Grant M, Epure L, Bokhari R, Roughley P, Antoniou J, Mwale F
Eur Cell Mater
. 2016 Jul;
32:137-51.
PMID: 27452962
The cartilaginous endplates (CEPs) are thin layers of hyaline cartilage found adjacent to intervertebral discs (IVDs). In addition to providing structural support, CEPs regulate nutrient and metabolic exchange in the...
2.
Cucchiarini M, Madry H, Guilak F, Saris D, Stoddart M, Koon Wong M, et al.
Eur Cell Mater
. 2014 May;
27:12-6.
PMID: 24802612
An AO Foundation (Davos, Switzerland) sponsored workshop "Cell Therapy in Cartilage Repair" from the Symposium "Where Science meets Clinics" (September 5-7, 2013, Davos) gathered leaders from medicine, science, industry, and...
3.
Parolin M, Gawri R, Mwale F, Steffen T, Roughley P, Antoniou J, et al.
Evid Based Spine Care J
. 2013 May;
1(2):67-8.
PMID: 23637672
Study Type: Basic science Objective: Low back pain is one of the most common health problems1 and is strongly associated with intervertebral disc degeneration, (IVD). Current treatments remove the symptoms...
4.
Wang D, Nasto L, Roughley P, Leme A, Houghton A, Usas A, et al.
Osteoarthritis Cartilage
. 2012 Apr;
20(8):896-905.
PMID: 22531458
Objective: To investigate the mechanisms by which chronic tobacco smoking promotes intervertebral disc degeneration (IDD) and vertebral degeneration in mice. Methods: Three month old C57BL/6 mice were exposed to tobacco...
5.
Amor I, Rauch F, Gruenwald K, Weis M, Eyre D, Roughley P, et al.
Am J Med Genet A
. 2011 Oct;
155A(11):2865-70.
PMID: 21964860
Mutations of proteins involved in posttranslational modification of collagen type I can cause osteogenesis imperfecta (OI) inherited in a recessive pattern. The cartilage-associated protein (CRTAP) is part of a heterotrimeric...
6.
Edouard T, Alos N, Chabot G, Roughley P, Glorieux F, Rauch F
J Clin Endocrinol Metab
. 2010 Oct;
96(1):82-9.
PMID: 20926527
Background: Pseudo-vitamin D deficiency rickets (PDDR; OMIM 264700) is a rare autosomal recessive disorder caused by mutations in the CYP27B1 gene, leading to an inability to synthesize 1α,25-dihydroxyvitamin D(3) (calcitriol)....
7.
Monfort J, Tardif G, Roughley P, Reboul P, Boileau C, Bishop P, et al.
Osteoarthritis Cartilage
. 2008 Jan;
16(7):749-55.
PMID: 18164633
Objective: One of the proteoglycan families is the small leucine-rich proteoglycans (SLRPs) that are characterized by their association with collagen fibrils and/or some glycosaminoglycans. Opticin is a glycoprotein and class...
8.
Rodriguez E, Roughley P
Osteoarthritis Cartilage
. 2006 Apr;
14(8):823-9.
PMID: 16584896
Objective: Loss of articular cartilage and intervertebral disc function in arthritis or disc degeneration is associated with degradation of the proteoglycan (PG) aggregates by either proteolysis of aggrecan or hyaluronan...
9.
Roughley P, Martens D, Rantakokko J, Alini M, Mwale F, Antoniou J
Eur Cell Mater
. 2006 Jan;
11:1-7.
PMID: 16425147
The functions of the intervertebral disc and of articular cartilage are intimately related to their aggrecan content. Aggrecan is a proteoglycan that interacts with hyaluronan to form large aggregates, which...
10.
Mwale F, Roughley P, Antoniou J
Eur Cell Mater
. 2004 Dec;
8:58-63.
PMID: 15602703
Tissue engineering of intervertebral discs (IVD) using mesenchymal stem cells (MSCs) induced to differentiate into a disc-cell phenotype has been considered as an alternative treatment for disc degeneration. However, since...