P R Holt
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Explore the profile of P R Holt including associated specialties, affiliations and a list of published articles.
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187
Citations
2230
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Recent Articles
1.
Bokulich N, Battaglia T, Aleman J, Walker J, Blaser M, Holt P
Clin Microbiol Infect
. 2016 Jan;
22(5):464-5.
PMID: 26806255
No abstract available.
2.
Agarwal B, Swaroop P, Protiva P, Raj S, Shirin H, Holt P
Apoptosis
. 2004 Jan;
8(6):649-54.
PMID: 14739610
The role of Cox-2 in NSAID-induced apoptosis is debated. We studied the role of Cox-2 inhibition in apoptosis induced by a selective Cox-2 inhibitor, SC236 (a structural analogue of celecoxib)...
3.
Holt P, Wolper C, Moss S, Yang K, Lipkin M
Nutr Cancer
. 2002 Jul;
41(1-2):150-5.
PMID: 12094618
Epidemiological evidence suggests that dietary calcium and vitamin D intake are inversely related to incidence of colon cancer. Previous studies have demonstrated that supplementation of the diet with calcium in...
4.
Yang W, Velcich A, Mariadason J, Nicholas C, Corner G, Houston M, et al.
Cancer Res
. 2001 Aug;
61(16):6297-302.
PMID: 11507085
Sulindac, a nonsteroidal anti-inflammatory drug, inhibits intestinal tumorigenesis in humans and rodents. Sulindac induced complex alterations in gene expression, but only 0.1% of 8063 sequences assayed were altered similarly by...
5.
Holt P
Gastroenterol Clin North Am
. 2001 Jul;
30(2):427-44.
PMID: 11432299
Physicians who care for elderly patients should be alert to the possible presence of diarrhea and malabsorption. Older patients may not admit to having chronic diarrhea, particularly if they also...
6.
Tangpricha V, Flanagan J, Whitlatch L, Tseng C, Chen T, Holt P, et al.
Lancet
. 2001 Jun;
357(9269):1673-4.
PMID: 11425375
Vitamin D affects calcium metabolism and prevents proliferation of colon cells in vitro. In human beings the main circulating form of vitamin D is 25-hydroxyvitamin D; to regulate calcium homoeostasis,...
7.
Moss S, Sordillo E, Abdalla A, Makarov V, Hanzely Z, Perez-Perez G, et al.
Cancer Res
. 2001 Mar;
61(4):1406-11.
PMID: 11245442
Gastric colonization by Helicobacter pylori is a risk factor for noncardia gastric cancer. The association between H. pylori and cancer may be attributable to increased epithelial cell turnover, possibly related...
8.
Shirin H, Pinto J, Kawabata Y, Soh J, Delohery T, Moss S, et al.
Cancer Res
. 2001 Feb;
61(2):725-31.
PMID: 11212275
Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced incidence of colon cancer in various human populations. Experimental carcinogenesis studies in animal models and in cell culture systems...
9.
Khaghan N, Holt P
Can J Gastroenterol
. 2000 Dec;
14(11):922-8.
PMID: 11125182
The increase in life expectancy demands that more attention be given to gastrointestinal problems, such as peptic ulcer disease, in elderly people. This review summarizes many of the physiological changes...
10.
Kidd M, Tang L, Modlin I, Zhang T, Chin K, Holt P, et al.
Digestion
. 2000 Oct;
62(2-3):143-51.
PMID: 11025361
Background/aims: Hypergastrinemia secondary to low acid secretion is associated with gastric carcinoid formation in Mastomys. We investigated the effect of gastrin on oxyntic epithelial apoptosis and proliferation in this model....