P P Zarrinkar
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Explore the profile of P P Zarrinkar including associated specialties, affiliations and a list of published articles.
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10
Citations
516
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Recent Articles
1.
Zarrinkar P, Mainquist J, Zamora M, Stern D, Welsh J, Sapinoso L, et al.
Genome Res
. 2001 Jul;
11(7):1256-61.
PMID: 11435408
Gene expression profiling using DNA arrays is rapidly becoming an essential tool for research and drug discovery and may soon play a central role in disease diagnosis. Although it is...
2.
Welsh J, Zarrinkar P, Sapinoso L, Kern S, Behling C, Monk B, et al.
Proc Natl Acad Sci U S A
. 2001 Feb;
98(3):1176-81.
PMID: 11158614
Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as...
3.
Zarrinkar P, Sullenger B
Biochemistry
. 1999 Mar;
38(11):3426-32.
PMID: 10079089
Group I ribozymes can repair mutant RNAs via trans-splicing. Unfortunately, substrate specificity is quite low for the trans-splicing reaction catalyzed by the group I ribozyme from Tetrahymenathermophila. We have used...
4.
Zarrinkar P, Sullenger B
Biochemistry
. 1999 Jan;
37(51):18056-63.
PMID: 9922174
One largely unexplored question about group I intron splicing is how the cleavage and ligation steps of the reaction are coordinated. We describe a simple in vitro trans-splicing model system...
5.
Treiber D, Rook M, Zarrinkar P, Williamson J
Science
. 1998 Apr;
279(5358):1943-6.
PMID: 9506945
In the magnesium ion-dependent folding of the Tetrahymena ribozyme, a kinetic intermediate accumulates in which the P4-P6 domain is formed, but the P3-P7 domain is not. The kinetic barriers to...
6.
Zarrinkar P, Wang J, Williamson J
RNA
. 1996 Jun;
2(6):564-73.
PMID: 8718685
Understanding the folding mechanisms of large, highly structured RNAs is important for understanding how these molecules carry out their function. Although models for the three-dimensional architecture of several large RNAs...
7.
Zarrinkar P, Williamson J
Nat Struct Biol
. 1996 May;
3(5):432-8.
PMID: 8612073
We have probed the nature of the individual kinetic steps in the folding of the Tetrahymena ribozyme by studying the folding kinetics of mutant ribozymes. After rapid formation of the...
8.
Zarrinkar P, Williamson J
Nucleic Acids Res
. 1996 Mar;
24(5):854-8.
PMID: 8600452
We have previously proposed a hierarchical model for the folding mechanism of the Tetrahymena ribozyme that may illustrate general features of the folding pathways of large RNAs. While the role...
9.
Zarrinkar P, Williamson J
Science
. 1994 Aug;
265(5174):918-24.
PMID: 8052848
The folding pathways of large, highly structured RNA molecules are largely unexplored. Insight into both the kinetics of folding and the presence of intermediates was provided in a study of...
10.
Adkisson 4th H, Risener Jr F, Zarrinkar P, Walla M, Christie W, Wuthier R
FASEB J
. 1991 Mar;
5(3):344-53.
PMID: 2001795
We report here the finding that normal, young cartilages, in distinction from all other tissues examined, have unusually high levels of n-9 eicosatrienoic (20:3 cis-delta 5,8,11) acid and low levels...