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P M MacFarlane

Explore the profile of P M MacFarlane including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 589
Followers 0
Related Specialties
Pulmonary Medicine
Physiology
Biology
Top 10 Co-Authors
G S Mitchell
C A Mayer
P B Frappell
R J Martin
S Vinit
J M Di Fiore
J E R Wilkerson
C G Wilson
M S Hoffman
N L Nichols
Published In
Respir Physiol Neurobiol
Am J Physiol Regul Integr Comp Physiol
J Appl Physiol (1985)
Neuroscience
J Physiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Human bone marrow-derived mesenchymal stem cells rescue neonatal CPAP-induced airway hyperreactivity
MacFarlane P, Mayer C, Caplan A, Raffay T, Mayer A, Bonfield T
Respir Physiol Neurobiol . 2022 Apr; 302:103913. PMID: 35436602
Continuous positive airway pressure (CPAP) is a primary non-invasive mode of respiratory support for preterm infants. However, emerging evidence suggests CPAP could be an underlying contributor to the unintended pathophysiology...
2.
Respiratory characteristics of the tammar wallaby pouch young and functional limitations in a newborn with skin gas exchange
MacFarlane P, Frappell P, Haase T
J Comp Physiol B . 2021 Apr; 191(6):995-1006. PMID: 33914108
A short gestation, low birth weight and presence of cutaneous exchange of O and CO comprise altricial features of newborn marsupials and that collectively implies a highly immature respiratory system....
3.
Caffeine prevents prostaglandin E-induced disturbances in respiratory control in neonatal rats: implications for infants with critical congenital heart disease
Mitchell L, Mayer C, Mayer A, Di Fiore J, Shein S, Raffay T, et al.
Am J Physiol Regul Integr Comp Physiol . 2020 Jun; 319(2):R233-R242. PMID: 32579854
Continuous infusion of prostaglandin E1 (PGE) is used to maintain ductus arteriosus patency in infants with critical congenital heart disease, but it can also cause central apnea suggesting an effect...
4.
Blood and urine biomarkers associated with long-term respiratory dysfunction following neonatal hyperoxia exposure: Implications for prematurity and risk of SIDS
Collada A, Mayer C, MacFarlane P
Respir Physiol Neurobiol . 2020 May; 279:103465. PMID: 32450147
Former preterm infants, many of whom required supplemental O support, exhibit sleep disordered breathing and attenuated ventilatory responses to acute hypoxia (HVR) beyond their NICU stay. There is an increasing...
5.
Respiratory dysfunction following neonatal sustained hypoxia exposure during a critical window of brain stem extracellular matrix formation
Stryker C, Camperchioli D, Mayer C, Alilain W, Martin R, MacFarlane P
Am J Physiol Regul Integr Comp Physiol . 2017 Oct; 314(2):R216-R227. PMID: 29046314
The extracellular matrix (ECM) modulates brain maturation and plays a major role in regulating neuronal plasticity during critical periods of development. We examined 1) whether there is a critical postnatal...
6.
Enhancement of phrenic long-term facilitation following repetitive acute intermittent hypoxia is blocked by the glycolytic inhibitor 2-deoxyglucose
MacFarlane P, Vinit S, Mitchell G
Am J Physiol Regul Integr Comp Physiol . 2017 Oct; 314(1):R135-R144. PMID: 29021191
Moderate acute intermittent hypoxia (mAIH) elicits a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). Preconditioning with modest protocols of chronic intermittent hypoxia enhances pLTF, demonstrating pLTF...
7.
Daily acute intermittent hypoxia improves breathing function with acute and chronic spinal injury via distinct mechanisms
Dougherty B, Terada J, Springborn S, Vinit S, MacFarlane P, Mitchell G
Respir Physiol Neurobiol . 2017 May; 256:50-57. PMID: 28549897
Daily acute intermittent hypoxia (dAIH) elicits respiratory plasticity, enhancing respiratory motor output and restoring breathing capacity after incomplete cervical spinal injuries (cSCI). We hypothesized that dAIH-induced functional recovery of breathing...
8.
Intratracheal LPS administration attenuates the acute hypoxic ventilatory response: Role of brainstem IL-1β receptors
Ribeiro A, Mayer C, Wilson C, Martin R, MacFarlane P
Respir Physiol Neurobiol . 2017 Mar; 242:45-51. PMID: 28330778
Perinatal inflammation and infection are commonly associated with various respiratory morbidities in preterm infants including apnea of prematurity. In this study, we investigated whether pulmonary inflammation via intra-tracheal micro-injection of...
9.
Microglia modulate brainstem serotonergic expression following neonatal sustained hypoxia exposure: implications for sudden infant death syndrome
MacFarlane P, Mayer C, Litvin D
J Physiol . 2015 Dec; 594(11):3079-94. PMID: 26659585
Key Points: Neonatal sustained hypoxia exposure modifies brainstem microglia and serotonin expression. The altered brainstem neurochemistry is associated with impaired ventilatory responses to acute hypoxia and mortality. The deleterious effects...
10.
Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure
Mayer C, Wilson C, MacFarlane P
Respir Physiol Neurobiol . 2014 Oct; 205:28-36. PMID: 25266393
We investigated whether pre-treatment with neonatal sustained hypoxia (SH) prior to chronic intermittent hypoxia (SH+CIH) would modify in vitro carotid body (CB) chemoreceptor activity and the excitability of neurons in...