P M Larsen
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Explore the profile of P M Larsen including associated specialties, affiliations and a list of published articles.
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56
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Recent Articles
1.
Rogowska-Wrzesinska A, Larsen P, Blomberg A, Gorg A, Roepstorff P, Norbeck J, et al.
Comp Funct Genomics
. 2008 Jul;
2(4):207-25.
PMID: 18628919
Yeast deletion strains created during gene function analysis projects very often show drastic phenotypic differences depending on the genetic background used. These results indicate the existence of important molecular differences...
2.
Nawrocki A, Fey S, Goffeau A, Roepstorff P, Larsen P
Proteomics
. 2001 Oct;
1(8):1022-32.
PMID: 11683503
Mutations in the yeast PDR1 or PDR3 genes lead to acquisition of resistance towards various unrelated cytotoxic compounds. The broad range and different properties of these compounds indicate the existence...
3.
Larsen M, Sorensen G, Fey S, Larsen P, Roepstorff P
Proteomics
. 2001 Oct;
1(2):223-38.
PMID: 11680869
Detection of phosphorylated proteins as well as assignment of the phosphorylated sites in such proteins is a major challenge in proteomics. In the present study we evaluate the use of...
4.
Nilsen S, Pedersen A, Moen M, Milsom I, Mattsson L, Iversen O, et al.
Maturitas
. 2001 Jul;
39(1):83-90.
PMID: 11451625
Objectives: To describe and compare attitudes, knowledge and management strategies concerning the prescription of hormone replacement therapy (HRT) between gynecologists from three Scandinavian countries. Design And Methods: In a cross-sectional...
5.
Larsen P, Fey S, Larsen M, Nawrocki A, Andersen H, KAHLER H, et al.
Diabetes
. 2001 May;
50(5):1056-63.
PMID: 11334408
The intracellular molecular events involved in the beta-cell death process are complex but poorly understood. Cytokines, e.g., interleukin (IL)-1beta, may play a crucial role in inducing this process. Protein synthesis...
6.
Larsen M, Larsen P, Fey S, Roepstorff P
Electrophoresis
. 2001 Mar;
22(3):566-75.
PMID: 11258770
Two-dimensional gel electrophoresis, bioinformatics, and mass spectrometry are key analysis tools in proteome analysis. The further characterization of post-translational modifications in gel-separated proteins relies fully on data obtained by mass...
7.
Fey S, Larsen P
Curr Opin Chem Biol
. 2001 Feb;
5(1):26-33.
PMID: 11166644
2D gel electrophoresis is the technology that everyone loves to hate-it requires manual dexterity and precision to reproduce precisely and is thus not well-suited as a high-throughput technology. Although almost...
8.
John N, Andersen H, Fey S, Larsen P, Roepstorff P, Larsen M, et al.
Diabetes
. 2000 Nov;
49(11):1819-29.
PMID: 11078448
Interleukin-1beta (IL-1beta) treatment of neonatal rat islets for 24 h induces changes in the expression of 105 of 2,200 proteins, as determined previously by two-dimensional (2D) gel electrophoresis. Nitric oxide...
9.
Christensen U, Larsen P, Fey S, Andersen H, Nawrocki A, Sparre T, et al.
Autoimmunity
. 2000 Aug;
32(1):1-15.
PMID: 10958170
Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2...
10.
Wildgruber R, Harder A, Obermaier C, Boguth G, Weiss W, Fey S, et al.
Electrophoresis
. 2000 Aug;
21(13):2610-6.
PMID: 10949137
The rising number of proteome projects leads to new challenges for two-dimensional electrophoresis with immobilized pH gradients and different applications of this technique. Not only wide pH gradients such as...