P M Colman
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Explore the profile of P M Colman including associated specialties, affiliations and a list of published articles.
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84
Citations
3368
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Recent Articles
1.
Robin A, Kumar K, Westphal D, Wardak A, Thompson G, Dewson G, et al.
Cell Death Dis
. 2015 Jul;
6:e1809.
PMID: 26158515
The BH3-only protein Bim is a potent direct activator of the proapoptotic effector protein Bax, but the structural basis for its activity has remained poorly defined. Here we describe the...
2.
Marshall B, Puthalakath H, Caria S, Chugh S, Doerflinger M, Colman P, et al.
Cell Death Dis
. 2015 Mar;
6:e1680.
PMID: 25766319
Subversion of host cell apoptosis is an important survival strategy for viruses to ensure their own proliferation and survival. Certain viruses express proteins homologous in sequence, structure and function to...
3.
Colman P, Air G, Webster R, Varghese J, Baker A, Lentz M, et al.
Immunol Today
. 2014 Oct;
8(11):323-6.
PMID: 25291054
Numerous studies have addressed the nature of antibody-antigen interaction, but only recently have three-dimensional structures of complexes of antibodies with protein antigens been reported, one with lysozyme and one with...
4.
Czabotar P, Colman P, Huang D
Cell Death Differ
. 2009 Jun;
16(9):1187-91.
PMID: 19557009
The mechanism by which the cell death mediator Bax becomes activated to cause mitochondrial damage, a key step for the intrinsic pathway to apoptosis, remain highly contentious. Although some data...
5.
Lee E, Chen L, Yang H, Colman P, Huang D, Fairlie W
Cell Death Differ
. 2008 Jun;
15(10):1609-18.
PMID: 18566606
Studies of the cell death pathway in the nematode Caenorhabditis elegans provided the first evidence of the evolutionary conservation of apoptosis signalling. Here we show that the worm Bcl-2 homology...
6.
Kvansakul M, Yang H, Fairlie W, Czabotar P, Fischer S, Perugini M, et al.
Cell Death Differ
. 2008 Jun;
15(10):1564-71.
PMID: 18551131
Apoptosis is an important part of the host's defense mechanism for eliminating invading pathogens. Some viruses express proteins homologous in sequence and function to mammalian pro-survival Bcl-2 proteins. Anti-apoptotic F1L...
7.
Lee E, Czabotar P, Smith B, Deshayes K, Zobel K, Colman P, et al.
Cell Death Differ
. 2007 Jun;
14(9):1711-3.
PMID: 17572662
No abstract available.
8.
Fairlie W, Perugini M, Kvansakul M, Chen L, Huang D, Colman P
Cell Death Differ
. 2005 Sep;
13(3):426-34.
PMID: 16167070
The pathway to cell death in Caenorhabditis elegans is well established. In cells undergoing apoptosis, the Bcl-2 homology domain 3 (BH3)-only protein EGL-1 binds to CED-9 at the mitochondrial membrane...
9.
Colman P
Expert Rev Anti Infect Ther
. 2005 May;
3(2):191-9.
PMID: 15918777
Zanamivir is the first of two registered neuraminidase inhibitors for the treatment and prophylaxis of influenza. Relenza, an orally inhaled powder form of zanamivir, is currently approved in 19 countries...
10.
Colman P
Vaccine
. 2002 Jul;
20 Suppl 2:S55-8.
PMID: 12110259
The description of the three-dimensional structure of the influenza virus neuraminidase in 1983 opened a new phase in the search for inhibitors of the enzyme. Two compounds in late development...