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P Lestage

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Articles 28
Citations 168
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Recent Articles
1.
Vandesquille M, Carrie I, Louis C, Beracochea D, Lestage P
J Psychopharmacol . 2011 Sep; 26(6):845-56. PMID: 21890586
Imbalance between GABAergic and glutamatergic neurotransmission has been recently hypothesized to trigger memory decline related either to ageing or to Alzheimer's disease (AD). Thereby, benzodiazepine-induced anterograde amnesia has been construed...
2.
Pirotte B, Francotte P, Goffin E, Fraikin P, Danober L, Lesur B, et al.
Curr Med Chem . 2010 Aug; 17(30):3575-82. PMID: 20738245
Amongst ionotropic glutamatergic receptors, the AMPA receptor subtype has been recognized as a major contributor to the fast excitatory neurotransmission in the central nervous system and the expression and maintenance...
3.
Tronche C, Lestage P, Louis C, Carrie I, Beracochea D
Behav Brain Res . 2010 Apr; 215(2):255-60. PMID: 20385172
Episodic memory deficits in elderly are due to the progressive weaknesses to use the contextual and temporal cues of the to be remembered information. Since the inability to remember the...
4.
BERT L, Favale D, Jego G, Greve P, Guilloux J, Guiard B, et al.
J Neurosci Methods . 2004 Dec; 140(1-2):53-7. PMID: 15589334
An important concern about microdialysis methodology is the histological validation of the dialysis probe implantation site in brain tissue of rodents (rat, mouse). Several methods have been described on standard...
5.
Sauzeon H, Lestage P, Raboutet C, NKaoua B, Claverie B
Brain Lang . 2004 Mar; 89(1):192-202. PMID: 15010250
Developmental changes in children's verbal fluency were explored in this study. One hundred and forty children aged from 7 to 16 completed four verbal fluency tasks, each with a different...
6.
Lestage P, Lockhart B, Roger A
Therapie . 2003 Apr; 57(6):554-63. PMID: 12666263
A "good" in vivo animal model of stroke must reproduce the etiology, anatomical, functional and metabolic consequences of human pathology and must also permit the study of anti-ischemic drugs in...
7.
Lockhart B, Closier M, Howard K, Steward C, Lestage P
Naunyn Schmiedebergs Arch Pharmacol . 2001 May; 363(4):429-38. PMID: 11330337
The potential interaction of acetylcholinesterase inhibitors with cholinergic receptors may play a significant role in the therapeutic and/or side-effects associated with this class of compound. In the present study, the...
8.
Lockhart B, Bonhomme N, Roger A, Dorey G, Casara P, Lestage P
Eur J Pharmacol . 2001 Apr; 416(1-2):59-68. PMID: 11282113
In a previous study Dorey et al. [Bio. Org. Chem. Lett., 10 (2000) 935] a series of novel dihydroquinoline compounds were developed, based on the potent antioxidant 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline (ethoxyquin), and...
9.
Lestage P
Therapie . 2000 Dec; 55(4):507-12. PMID: 11098728
Today, the memory is regarded as a network of memories which is sustained by distinct interconnected neuronal pathways. These diverse neuronal pathways are differentially impaired during cerebral ageing. Consequently, according...
10.
Goldstein S, Lestage P
Curr Med Chem . 2000 Oct; 7(12):1255-67. PMID: 11032970
Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be...