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P Le Souef

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Articles 18
Citations 536
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Recent Articles
1.
Bjerregaard A, Laing I, Backer V, Sverrild A, Khoo S, Chidlow G, et al.
Clin Exp Allergy . 2017 Apr; 47(8):1007-1013. PMID: 28390083
Background: The major trigger of asthma exacerbations is infection with a respiratory virus, most commonly rhinovirus. Type 2 inflammation is known to be associated with an increased risk of exacerbations...
2.
Custovic A, Johnston S, Pavord I, Gaga M, Fabbri L, Bel E, et al.
Allergy . 2014 Jan; 68(12):1520-31. PMID: 24410781
Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function and, in childhood, are linked...
3.
Papadopoulos N, Arakawa H, Carlsen K, Custovic A, Gern J, Lemanske R, et al.
Allergy . 2012 Jun; 67(8):976-97. PMID: 22702533
Asthma is the most common chronic lower respiratory disease in childhood throughout the world. Several guidelines and/or consensus documents are available to support medical decisions on pediatric asthma. Although there...
4.
Baynam G, Walters M, Claes P, Le Souef P
Med Hypotheses . 2012 Feb; 78(4):497-501. PMID: 22289344
We propose that, given shared evolutionarily factors mediate vaccine response and facial development, objective, high-resolution 3D facial analysis can be employed to investigate phenomena underlying vaccine response/failure. To account for...
5.
Brand P, Baraldi E, Bisgaard H, Boner A, Castro-Rodriguez J, Custovic A, et al.
Eur Respir J . 2008 Oct; 32(4):1096-110. PMID: 18827155
There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze...
6.
Turner S, Zhang G, Young S, Cox M, Goldblatt J, Landau L, et al.
Thorax . 2007 Oct; 63(3):234-9. PMID: 17905824
Background: A study was undertaken to examine factors that might influence lung function during infancy and to test the hypothesis that change in weight during infancy is negatively associated with...
7.
Ferreira M, OGorman L, Le Souef P, Burton P, Toelle B, Robertson C, et al.
Allergy . 2006 Jan; 61(2):245-53. PMID: 16409204
Background: Intermediate phenotypes are often measured as a proxy for asthma. It is largely unclear to what extent the same set of environmental or genetic factors regulate these traits. Objective:...
8.
Heaton T, Rowe J, Turner S, Aalberse R, de Klerk N, Suriyaarachchi D, et al.
Lancet . 2005 Jan; 365(9454):142-9. PMID: 15639296
Background: Increasing evidence suggests that patterns of T-cell immunity to inhalant allergens in genetically diverse human populations are more heterogeneous than previously assumed, and that covert differences in expression patterns...
9.
Le Souef P
Pediatr Allergy Immunol . 2000 Oct; 11 Suppl 13:15-8. PMID: 11048765
Infants who wheeze are likely to have narrowed or overly compliant airways rather than atopy. After around 3 years of age, airway responsiveness and atopy are associated with the development...
10.
Le Souef P
Allergy . 1999 Jul; 54 Suppl 49:93-6. PMID: 10422755
For a physician to understand how to prescribe appropriate doses of drugs via aerosol requires a basic understanding of the technical issues involved. Drugs are usually prescribed in terms of...