P L Beales
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Explore the profile of P L Beales including associated specialties, affiliations and a list of published articles.
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19
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1020
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Recent Articles
1.
Fu S, Thompson C, Ali A, Wang W, Chapple J, Mitchison H, et al.
Osteoarthritis Cartilage
. 2019 Mar;
27(7):1064-1074.
PMID: 30922983
Objective: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and...
2.
Thompson C, Plant J, Wann A, Bishop C, Novak P, Mitchison H, et al.
Eur Cell Mater
. 2017 Sep;
34:128-141.
PMID: 28929469
Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying...
3.
Forsythe E, Sparks K, Hoskins B, Bagkeris E, McGowan B, Carroll P, et al.
Clin Genet
. 2014 Mar;
87(4):343-9.
PMID: 24611735
Bardet-Biedl syndrome is a rare ciliopathy characterized by retinal dystrophy, obesity, intellectual disability, polydactyly, hypogonadism and renal impairment. Patients are at high risk of cardiovascular disease. Mutations in BBS1 and...
4.
An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1)
Selman L, Henriksen M, Brandt J, Palarasah Y, Waters A, Beales P, et al.
J Immunol Methods
. 2012 Feb;
375(1-2):182-8.
PMID: 22301270
Collectin 11 (CL-11), also referred to as collectin kidney 1 (CL-K1), is a pattern recognition molecule that belongs to the collectin group of proteins involved in innate immunity. It interacts...
5.
Harville H, Held S, Diaz-Font A, Davis E, Diplas B, Lewis R, et al.
J Med Genet
. 2009 Oct;
47(4):262-7.
PMID: 19797195
Background: Bardet-Biedl syndrome (BBS) is primarily an autosomal recessive disorder characterised by the five cardinal features retinitis pigmentosa, postaxial polydactyly, mental retardation, obesity and hypogenitalism. In addition, renal cysts and...
6.
De Pontual L, Pelet A, Clement-Ziza M, Trochet D, Antonarakis S, Attie-Bitach T, et al.
Hum Mutat
. 2007 Apr;
28(8):790-6.
PMID: 17397038
Hirschsprung disease (HSCR) stands as a model for genetic dissection of complex diseases. In this model, a major gene, RET, is involved in most if not all cases of isolated...
7.
Barnett S, Reilly S, Carr L, Ojo I, Beales P, Charman T
J Med Genet
. 2002 Dec;
39(12):e76.
PMID: 12471214
No abstract available.
8.
Becker K, Beales P, Calver D, Matthijs G, Mohammed S
J Med Genet
. 2002 Feb;
39(1):68-71.
PMID: 11826030
No abstract available.
9.
Katsanis N, Lupski J, Beales P
Hum Mol Genet
. 2001 Oct;
10(20):2293-9.
PMID: 11673413
Few autosomal recessive disorders display the degree of pleiotropism and genetic heterogeneity found in Bardet-Biedl syndrome (BBS), a genetic disorder characterized primarily by retinal dystrophy, obesity, polydactyly, cognitive impairment and...
10.
Katsanis N, Ansley S, Badano J, Eichers E, Lewis R, Hoskins B, et al.
Science
. 2001 Sep;
293(5538):2256-9.
PMID: 11567139
Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by multiple clinical features that include pigmentary retinal dystrophy, polydactyly, obesity, developmental delay, and renal defects. BBS is considered an autosomal...