P K Denbesten
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Explore the profile of P K Denbesten including associated specialties, affiliations and a list of published articles.
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42
Citations
633
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Recent Articles
1.
The C-terminus of amelogenin enhances osteogenic differentiation of human cementoblast lineage cells
Kunimatsu R, Yoshimi Y, Hirose N, Awada T, Miyauchi M, Takata T, et al.
J Periodontal Res
. 2016 May;
52(2):218-224.
PMID: 27146486
Background And Objectives: Amelogenin proteins are the major constituent of developing extracellular enamel matrix and are believed to have an exclusively epithelial origin. Recent studies have suggested that amelogenins might...
2.
Bronckers A, Lyaruu D, Jalali R, Medina J, Zandieh-Doulabi B, Denbesten P
J Dent Res
. 2015 Sep;
94(12):1740-7.
PMID: 26403673
Ameloblasts express transmembrane proteins for transport of mineral ions and regulation of pH in the enamel space. Two major transporters recently identified in ameloblasts are the Na(+)K(+)-dependent calcium transporter NCKX4...
3.
Jalali R, Zandieh-Doulabi B, Denbesten P, Seidler U, Riederer B, Wedenoja S, et al.
J Dent Res
. 2015 Sep;
94(12):1732-9.
PMID: 26394631
Formation of apatite crystals during enamel development generates protons. To sustain mineral accretion, maturation ameloblasts need to buffer these protons. The presence of cytosolic carbonic anhydrases, the basolateral Na(+) bicarbonate...
4.
Guo J, Lyaruu D, Takano Y, Gibson C, Denbesten P, Bronckers A
J Dent Res
. 2014 Dec;
94(3):412-20.
PMID: 25535204
Amelogenins are the most abundant protein species in forming dental enamel, taken to regulate crystal shape and crystal growth. Unprotonated amelogenins can bind protons, suggesting that amelogenins could regulate the...
5.
NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse
Jalali R, Guo J, Zandieh-Doulabi B, Bervoets T, Paine M, Boron W, et al.
Cell Tissue Res
. 2014 Jul;
358(2):433-42.
PMID: 25012520
During the formation of dental enamel, maturation-stage ameloblasts express ion-transporting transmembrane proteins. The SLC4 family of ion-transporters regulates intra- and extracellular pH in eukaryotic cells by cotransporting HCO3 (-) with...
6.
Katsura K, Horst J, Chandra D, Le T, Nakano Y, Zhang Y, et al.
Matrix Biol
. 2014 Jul;
38:48-58.
PMID: 25008349
Amelogenesis Imperfecta (AI) is a clinical diagnosis that encompasses a group of genetic mutations, each affecting processes involved in tooth enamel formation and thus, result in various enamel defects. The...
7.
Lyaruu D, Vermeulen L, Stienen N, Bervoets T, Denbesten P, Bronckers A
Caries Res
. 2012 Sep;
46(6):575-80.
PMID: 22947666
Excessive intake of fluoride (F) by young children results in the formation of enamel subsurface porosities and pits, called enamel fluorosis. In this study, we used a single high dose...
8.
Zhan L, Cheng J, Chang P, Ngo M, Denbesten P, Hoover C, et al.
J Dent Res
. 2012 Jun;
91(7 Suppl):85S-90S.
PMID: 22699675
The aim of the study was to investigate the efficacy of the use of xylitol-containing tooth-wipes in preventing dental caries in young children. In a double-blinded randomized controlled clinical trial,...
9.
Sire J, Huang Y, Li W, Delgado S, Goldberg M, Denbesten P
J Dent Res
. 2011 Sep;
91(1):84-9.
PMID: 21948850
Amelogenin gene organization varies from 6 exons (1,2,3,5,6,7) in amphibians and sauropsids to 10 in rodents. The additional exons are exons 4, 8, 9, and "4b", the latter being as...
10.
Zheng L, Zhang Y, He P, Kim J, Schneider R, Bronckers A, et al.
J Dent Res
. 2011 Mar;
90(6):782-7.
PMID: 21364089
Enamel biomineralization results in a release of protons into the enamel matrix, causing an acidification of the local microenvironment. This acidification, which may be enhanced by more rapid mineral deposition...