P J Trainer
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Explore the profile of P J Trainer including associated specialties, affiliations and a list of published articles.
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103
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1719
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Recent Articles
1.
Higham C, Olsson-Brown A, Carroll P, Cooksley T, Larkin J, Lorigan P, et al.
Endocr Connect
. 2018 Jun;
7(7):G1-G7.
PMID: 29930025
Immunotherapy treatment with checkpoint inhibitors (CPI) (CTLA-4 and PD-1 inhibitors) significantly improves survival in a number of cancers. Treatment can be limited by immune-mediated adverse effects including endocrinopathies such as...
2.
Valassi E, Crespo I, Keevil B, Aulinas A, Urgell E, Santos A, et al.
Eur J Endocrinol
. 2016 Dec;
176(2):221-231.
PMID: 27932530
Objective: Affective alterations and poorer quality of life often persist in patients with Cushing's syndrome (CS) in remission. Brain-derived neurotrophic factor (BDNF) regulates the hypothalamic-pituitary-adrenal axis (HPA) and is highly...
3.
Monaghan P, Kyriacou A, Sturgeon C, Davies A, Trainer P, White A, et al.
Clin Endocrinol (Oxf)
. 2016 Jun;
85(4):569-74.
PMID: 27256168
Objective: It is recognized that measurement of ACTH-precursor peptides including proopiomelanocortin (POMC) has clinical utility in identifying the aetiology of Cushing's syndrome. Recent data have also demonstrated cross-reactivity of POMC...
4.
Monaghan P, Lamarca A, Valle J, Hubner R, Mansoor W, Trainer P, et al.
Clin Endocrinol (Oxf)
. 2015 Nov;
84(3):348-52.
PMID: 26608723
Objective: Chromogranin A (CgA) and B (CgB) are markers for monitoring disease status in patients with gastroenteropancreatic neuroendocrine tumours (NETs). These are specialized diagnostic tests often necessitating referral of specimens...
5.
Higham C, Atkinson A, Aylwin S, Bidlingmaier M, Drake W, Lewis A, et al.
J Clin Endocrinol Metab
. 2012 Jan;
97(4):1187-93.
PMID: 22278424
Context: With adequate dose titration, pegvisomant normalizes IGF-I in up to 97% of patients with acromegaly. Pegvisomant is indicated for treatment-resistant disease but is expensive, particularly at a high dose....
6.
Perogamvros I, Kayahara M, Trainer P, Ray D
Clin Endocrinol (Oxf)
. 2011 Apr;
75(1):31-8.
PMID: 21521274
Context: Corticosteroid-binding globulin (CBG) is the principal carrier of natural glucocorticoids in the circulation, and we hypothesized that it modulates glucocorticoid bioactivity (GBA). Alterations in CBG, the presence of noncortisol,...
7.
Paisley A, Banerjee M, Rezai M, Schofield R, Balakrishnannair S, Herbert A, et al.
J Clin Endocrinol Metab
. 2011 Feb;
96(5):1486-92.
PMID: 21346071
Context: Acromegaly increases cardiovascular morbidity. We tested the hypothesis that increased arterial stiffness together with left ventricular hypertrophy may be a contributory factor. Patients And Design: Fifty-six patients (40 males,...
8.
Perogamvros I, Aarons L, Miller A, Trainer P, Ray D
Clin Endocrinol (Oxf)
. 2010 Nov;
74(1):30-6.
PMID: 21054475
Objective: Corticosteroid-binding globulin (CBG) is the principal carrier for cortisol in the circulation. Variations in CBG-binding capacity are predicted to alter total serum cortisol disposition, but free serum cortisol is...
9.
Perogamvros I, Keevil B, Ray D, Trainer P
J Clin Endocrinol Metab
. 2010 Aug;
95(11):4951-8.
PMID: 20685855
Context: Salivary cortisol measurement is used as a practical surrogate for serum free cortisol. However, parotid tissue harbors 11β-hydroxysteroid dehydrogenase (11β-HSD2) activity converting cortisol to cortisone. Objective: This study was...
10.
Perogamvros I, Underhill C, Henley D, Hadfield K, Newman W, Ray D, et al.
J Clin Endocrinol Metab
. 2010 Jul;
95(10):E142-50.
PMID: 20610591
Background: Corticosteroid-binding globulin (CBG) is the principal carrier for glucocorticoids in the circulation and a regulator of their bioavailability. Inherited CBG deficiencies are rarely reported, and only three causative mutations...