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P J Sadler

Explore the profile of P J Sadler including associated specialties, affiliations and a list of published articles. Areas
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Articles 137
Citations 1609
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Recent Articles
1.
Coverdale J, Bedford R, Carter O, Cao S, Wills M, Sadler P
Chembiochem . 2024 May; 25(15):e202400374. PMID: 38785030
Anticancer agents that exhibit catalytic mechanisms of action offer a unique multi-targeting strategy to overcome drug resistance. Nonetheless, many in-cell catalysts in development are hindered by deactivation by endogenous nucleophiles....
2.
Carter R, Westhorpe A, Romero M, Habtemariam A, Gallevo C, Bark Y, et al.
Sci Rep . 2016 Feb; 6:20596. PMID: 26867983
Some of the largest improvements in clinical outcomes for patients with solid cancers observed over the past 3 decades have been from concurrent treatment with chemotherapy and radiotherapy (RT). The...
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Unterkofler S, McQuitty R, Euser T, Farrer N, Sadler P, Russell P
Opt Lett . 2012 Jun; 37(11):1952-4. PMID: 22660084
Liquid-filled hollow-core photonic crystal fibers (HC-PCFs) are perfect optofluidic channels, uniquely providing low-loss optical guidance in a liquid medium. As a result, the overlap of the dissolved specimen and the...
5.
Bergamo A, Masi A, Peacock A, Habtemariam A, Sadler P, Sava G
J Inorg Biochem . 2009 Nov; 104(1):79-86. PMID: 19906432
We have compared the organometallic arene complexes [(eta(6)-biphenyl)M(ethylenediamine)Cl](+) RM175 (M=Ru(II)) and its isostructural osmium(II) analogue AFAP51 (M=Os(II)) for their ability to induce cell detachment resistance from fibronectin, collagen IV and...
6.
Best S, Guo Z, Djuran M, Sadler P
Met Based Drugs . 2008 May; 6(4-5):261-9. PMID: 18475901
The solution behaviour of the square-planar gold(III) complex [Au(dien)Cl]Cl(2) (dien = 1,5- diamino-3-azapentane) was investigated by (13)H and (13)C NMR spectroscopy. We have found that (1)H NMR spectra of [Au(dien)Cl]...
7.
Sevillano P, Garcia M, Habtemariam A, Parsons S, Sadler P
Met Based Drugs . 2008 May; 6(4-5):211-21. PMID: 18475895
The following gold(I) and silver(I) complexes of the tritertiary phosphine 1,1,1- tris(diphenylphosphinomethyl)ethane, tripod , have been synthesised: Au(3)(tripod)X(3) [X = Cl(1), Br(2), I(3)]; [Au(3)(tripod)(2)Cl(2)]Cl (4); Au(tripod)X [X = Br(5), I(6)];...
8.
Guichard S, Else R, Reid E, Zeitlin B, Aird R, Muir M, et al.
Biochem Pharmacol . 2005 Dec; 71(4):408-15. PMID: 16360645
Novel ruthenium(II) organo-metallic compounds are active in ovarian cancer models [Aird RE, Cummings J, Ritchie AA, Muir M, Morris RE, Chen H, et al. In vitro and in vivo activity...
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Sherwin J, Awad I, Sadler P, LIDDLE A, Rowbotham D
Anaesthesia . 2003 May; 58(5):474-6. PMID: 12751506
We compared the effect of lidocaine injection with lidocaine iontophoresis for pain relief during radial artery cannulation prior to induction of anaesthesia. Patients were allocated randomly to one of two...
10.
Vinje J, Parkinson J, Sadler P, Brown T, Sletten E
Chemistry . 2003 Mar; 9(7):1620-30. PMID: 12658661
Reactions of [PtCl(dien)](+) (dien=diethylenetriamine), Mn(2+) and Zn(2+) ions with three different double-helical oligodeoxyribonucleotides, which contain the central sequence GGXY (XY=AT, TA or CC) have been monitored by NMR spectroscopy. 2...