P J Meffin
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Explore the profile of P J Meffin including associated specialties, affiliations and a list of published articles.
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Articles
66
Citations
570
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Recent Articles
1.
Sallustio B, Knights K, Meffin P
Biochem Pharmacol
. 1990 Sep;
40(6):1414-7.
PMID: 2403395
No abstract available.
2.
Sallustio B, Purdie Y, Birkett D, Meffin P
J Pharmacol Exp Ther
. 1989 Oct;
251(1):288-94.
PMID: 2795462
Drugs which are cleared predominantly by forming acyl-glucuronides undergo a futile cycle in which plasma drug clearance is a function of the formation, hydrolysis and renal clearance of the glucuronide...
3.
Sallustio B, Purdie Y, Whitehead A, Ahern M, Meffin P
Br J Clin Pharmacol
. 1988 Dec;
26(6):765-70.
PMID: 3242582
1. The disposition of ketoprofen enantiomers was studied in 21 patients taking racemic ketoprofen (Orudis SR). 2. In each patient the plasma concentrations of the R- and S-enantiomers were similar...
4.
Knights K, Drew R, Meffin P
Biochem Pharmacol
. 1988 Oct;
37(19):3539-42.
PMID: 3178867
No abstract available.
5.
Sallustio B, Meffin P, Knights K
Biochem Pharmacol
. 1988 May;
37(10):1919-23.
PMID: 3377800
The formation of triacylglycerols containing fenoprofen was studied in rat isolated adipocytes and hepatocytes incubated with [3H]glycerol and R or S fenoprofen. In both hepatocytes and adipocytes there was a...
6.
Sallustio B, Meffin P, Thompson M
J Chromatogr
. 1987 Nov;
422:33-41.
PMID: 3437022
A normal-phase high-performance liquid chromatographic (HPLC) method has been developed for the quantitation of radiolabelled triacylglycerols containing fenoprofen, synthesized from [3H]glycerol by isolated hepatocytes and adipocytes. The assay consists of...
7.
Abas A, Meffin P
J Pharmacol Exp Ther
. 1987 Feb;
240(2):637-41.
PMID: 3806417
The disposition of ketoprofen enantiomers has been studied in 12 rabbits with normal renal function (control) and in 6 of these rabbits with renal dysfunction. In control animals a mean...
8.
Hayball P, Meffin P
J Pharmacol Exp Ther
. 1987 Feb;
240(2):631-6.
PMID: 3806416
The disposition of fenoprofen enantiomers has been studied in nine healthy rabbits. A mean (S.E.M.) of 0.73 (0.07) of R-fenoprofen was inverted to S-fenoprofen and the distribution volumes for bound...
9.
Jones M, Sallustio B, Purdie Y, Meffin P
J Pharmacol Exp Ther
. 1986 Jul;
238(1):288-94.
PMID: 3723401
The binding of 2-phenylpropionic acid (2PPA) enantiomers to rabbit albumin has been studied using fatty-acid-free albumin, with and without oleic acid, and using plasma from control rabbits and from rabbits...
10.
Meffin P, Sallustio B, Purdie Y, Jones M
J Pharmacol Exp Ther
. 1986 Jul;
238(1):280-7.
PMID: 3723400
The disposition of 2-phenylpropionic acid (2PPA) enantiomers has been studied in 12 rabbits with normal renal function (control) and in 6 rabbits with renal dysfunction. In control animals a mean...