P J Halsall
Overview
Explore the profile of P J Halsall including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
309
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Recent Articles
1.
Glahn K, Ellis F, Halsall P, Muller C, Snoeck M, Urwyler A, et al.
Br J Anaesth
. 2010 Sep;
105(4):417-20.
PMID: 20837722
Survival from a malignant hyperthermia (MH) crisis is highly dependent on early recognition and prompt action. MH crises are very rare and an increasing use of total i.v. anaesthesia is...
2.
Carpenter D, Robinson R, Quinnell R, Ringrose C, Hogg M, Casson F, et al.
Br J Anaesth
. 2009 Aug;
103(4):538-48.
PMID: 19648156
Background: Malignant hyperthermia (MH) is associated, in the majority of cases, with mutations in RYR1, the gene encoding the skeletal muscle ryanodine receptor. Our primary aim was to assess whether...
3.
Robinson R, Carpenter D, Halsall P, Iles D, Booms P, Steele D, et al.
Br J Anaesth
. 2009 May;
103(2):220-5.
PMID: 19454545
Background: Tissue-specific monoallelic silencing of the RYR1 gene has been proposed as an explanation for variable penetrance of dominant RYR1 mutations in malignant hyperthermia (MH). We examined the hypothesis that...
4.
Carpenter D, Morris A, Robinson R, Booms P, Iles D, Halsall P, et al.
Ann Hum Genet
. 2008 Oct;
73(1):10-8.
PMID: 18945287
This study represents a new approach to characterising patients at risk of malignant hyperthermia (MH) through the use of a recently published method for identifying high-risk haplotypes in candidate genes....
5.
Halsall P, Robinson R
Handb Clin Neurol
. 2008 Sep;
86:107-24.
PMID: 18808997
No abstract available.
6.
Duke A, Hopkins P, Halsall P, Steele D
Br J Anaesth
. 2006 Jul;
97(3):320-8.
PMID: 16849381
Background: In normal resting muscle, cytosolic Mg(2+) exerts a potent inhibitory influence on the sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR1). Impaired Mg(2+)-regulation of RyR1 has been proposed...
7.
Johi R, Mills R, Halsall P, Hopkins P
Br J Anaesth
. 2003 Oct;
91(5):744-7.
PMID: 14570802
Central core disease and malignant hyperthermia (MH) are both associated with mutations in the RYR1 gene. We report the anaesthetic management of one such patient presenting for coronary artery bypass...
8.
Wappler F, Anetseder M, Baur C, Censier K, Doetsch S, Felleiter P, et al.
Eur J Anaesthesiol
. 2003 Jul;
20(7):528-36.
PMID: 12884985
Background And Objective: The in vitro contracture test with halothane and caffeine is the gold standard for the diagnosis of susceptibility to malignant hyperthermia (MH). However, the sensitivity of the...
9.
Urwyler A, Halsall P, Mueller C, Robinson R
Acta Anaesthesiol Scand
. 2003 Apr;
47(4):492; author reply 493.
PMID: 12694155
No abstract available.
10.
Brooks C, Robinson R, Halsall P, Hopkins P
Br J Anaesth
. 2002 Jun;
88(4):587-9.
PMID: 12066739
Background: Malignant hyperthermia (MH) is an inherited, potentially fatal, pharmocogenetic disorder triggered by certain anaesthetic agents. In light of the reported genetic heterogeneity for the disorder and the recent introduction...